Fluoroquinolone Resistance among Clonal Complex 1 Group B Streptococcus Strains

الملخص EN

Fluoroquinolone resistance in group B Streptococcus is increasingly being reported worldwide.

Here, we correlated fluoroquinolone resistance with mutations in gyrA, gyrB, parC, and parE genes, identified by mining whole-genome sequencing (WGS) data of 190 clonal complex 1 group B Streptococcus strains recovered from patients with invasive diseases in North America.

We report a high prevalence of fluoroquinolone resistance (12%) among GBS strains in our collection.

Our approach is the first step towards accurate prediction of fluoroquinolone resistance from WGS data in this opportunistic pathogen.