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A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2
المؤلفون المشاركون
Dunham, Ann
Chen, Paula X.
Chen, Michelle
Huynh, Milan
Rheingold, Evan
Prosper, Olivia
Wallace, Dorothy
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-01
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Researchers have observed that response of tumor cells to treatment varies depending on whether the cells are grown in monolayer, as in vitro spheroids or in vivo.
This study uses data from the literature on monolayer treatment of SK-N-SH neuroblastoma cells with 15-deoxy-PGJ2 and couples it with data on growth rates for untreated SK-N-SH neuroblastoma cells grown as multicellular spheroids.
A linear model is constructed for untreated and treated monolayer data sets, which is tuned to growth, death, and cell cycle data for the monolayer case for both control and treatment with 15-deoxy-PGJ2.
The monolayer model is extended to a five-dimensional nonlinear model of in vitro tumor spheroid growth and treatment that includes compartments of the cell cycle (G1,S,G2/M) as well as quiescent (Q) and necrotic (N) cells.
Monolayer treatment data for 15-deoxy-PGJ2 is used to derive a prediction of spheroid response under similar treatments.
For short periods of treatment, spheroid response is less pronounced than monolayer response.
The simulations suggest that the difference in response to treatment of monolayer versus spheroid cultures observed in laboratory studies is a natural consequence of tumor spheroid physiology rather than any special resistance to treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wallace, Dorothy& Dunham, Ann& Chen, Paula X.& Chen, Michelle& Huynh, Milan& Rheingold, Evan…[et al.]. 2016. A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2. Computational and Mathematical Methods in Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1100116
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wallace, Dorothy…[et al.]. A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2. Computational and Mathematical Methods in Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1100116
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wallace, Dorothy& Dunham, Ann& Chen, Paula X.& Chen, Michelle& Huynh, Milan& Rheingold, Evan…[et al.]. A Model for Spheroid versus Monolayer Response of SK-N-SH Neuroblastoma Cells to Treatment with 15-Deoxy-PGJ2. Computational and Mathematical Methods in Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1100116
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100116
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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