![](/images/graphics-bg.png)
Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency
المؤلف
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-19
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Context.
Transient secondary adrenal insufficiency (SAI) is an expected complication following successful adenomectomy of ACTH-secreting pituitary adenomas or unilateral adrenalectomy for cortisol-secreting adrenal adenomas.
To date, no pharmacological therapy has been shown to hasten recovery of the hypothalamic-pituitary-adrenal (HPA) axis in this clinical scenario.
Case Description.
A 33-year-old woman underwent uncomplicated unilateral adrenalectomy for a 3.7 cm cortisol-secreting adrenal adenoma.
Postoperatively, she developed SAI and was placed on hydrocortisone 15 mg/day, given in divided doses.
In the ensuing six years, the patient’s HPA axis failed to recover and she remained corticosteroid-dependent.
Quarterly biochemical testing (after withholding hydrocortisone for 18 hours) consistently yielded undetectable serum cortisol and subnormal plasma ACTH levels.
While she was on hydrocortisone 15 mg/day, mifepristone was initiated and gradually titrated to a maintenance dose of 600 mg/day after 5 months.
Rapid recovery of the HPA axis was subsequently noted with ACTH rising into the supranormal range at 4 months followed by a subsequent rise in cortisol levels into the normal range.
After 6 months, the dose of hydrocortisone and mifepristone was lowered and both were ultimately stopped after 8 months.
The HPA axis remains normal after an additional 16 months of follow-up.
Conclusion.
Mifepristone successfully restored the HPA axis in a woman with prolonged secondary adrenal insufficiency (SAI) after adrenalectomy for Cushing’s syndrome (CS).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cohan, Pejman. 2016. Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency. Case Reports in Endocrinology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100685
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cohan, Pejman. Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency. Case Reports in Endocrinology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1100685
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cohan, Pejman. Mifepristone Accelerates HPA Axis Recovery in Secondary Adrenal Insufficiency. Case Reports in Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1100685
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100685
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)