Occult Langerhans Cell Histiocytosis Presenting with Papillary Thyroid Carcinoma, a Thickened Pituitary Stalk and Diabetes Insipidus
المؤلفون المشاركون
Gordon, Murray B.
Gordon, Michael S.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-30
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Etiologies of a thickened stalk include inflammatory, neoplastic, and idiopathic origins, and the underlying diagnosis may remain occult.
We report a patient with a thickened pituitary stalk (TPS) and papillary thyroid carcinoma (PTC) whose diagnosis remained obscure until a skin lesion appeared.
The patient presented with PTC, status postthyroidectomy, and I131 therapy.
PTC molecular testing revealed BRAF mutant (V600E, GTC>GAG).
She had a 5-year history of polyuria/polydipsia.
Overnight dehydration study confirmed diabetes insipidus (DI).
MRI revealed TPS with loss of the posterior pituitary bright spot.
Evaluation showed hypogonadotropic hypogonadism and low IGF-1.
Chest X-ray and ACE levels were normal.
Radiographs to evaluate for extrapituitary sites of Langerhans Cell Histiocytosis (LCH) were unremarkable.
Germinoma studies were negative: normal serum and CSF beta-hCG, alpha-fetoprotein, and CEA.
Three years later, the patient developed vulvar labial lesions followed by inguinal region skin lesions, biopsy of which revealed LCH.
Reanalysis of thyroid pathology was consistent with concurrent LCH, PTC, and Hashimoto’s thyroiditis within the thyroid.
This case illustrates that one must be vigilant for extrapituitary manifestations of systemic diseases to diagnose the etiology of TPS.
An activating mutation of the protooncogene BRAF is a potential unifying etiology of both PTC and LCH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gordon, Michael S.& Gordon, Murray B.. 2016. Occult Langerhans Cell Histiocytosis Presenting with Papillary Thyroid Carcinoma, a Thickened Pituitary Stalk and Diabetes Insipidus. Case Reports in Endocrinology،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100688
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gordon, Michael S.& Gordon, Murray B.. Occult Langerhans Cell Histiocytosis Presenting with Papillary Thyroid Carcinoma, a Thickened Pituitary Stalk and Diabetes Insipidus. Case Reports in Endocrinology No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1100688
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gordon, Michael S.& Gordon, Murray B.. Occult Langerhans Cell Histiocytosis Presenting with Papillary Thyroid Carcinoma, a Thickened Pituitary Stalk and Diabetes Insipidus. Case Reports in Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100688
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100688
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر