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Primary Myelofibrosis Presenting as Extramedullary Hematopoiesis in a Transplanted Liver Graft: Case Report and Review of the Literature
المؤلفون المشاركون
Yacoub, Abdulraheem
Mohyuddin, Ghulam Rehman
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-3، 3ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-17
دولة النشر
مصر
عدد الصفحات
3
التخصصات الرئيسية
الملخص EN
Primary myelofibrosis (PMF) commonly results in extramedullary hematopoiesis (EMH) in the spleen and liver as well as a variety of other organs.
We present a first report of a unique presentation of PMF in a liver transplant recipient patient as EMH in the transplanted liver graft.
A 76-year-old man with history of cryptogenic cirrhosis received cadaveric liver transplantation in 1996.
He maintained a normal graft function and stable hematologic parameters until 2013 when he presented with anemia and progressive fatigue.
Extensive work-up did not identify the etiology of the recent decline in his hemoglobin; thus a liver biopsy was done which showed findings of EMH within the sinusoids with increased megakaryocytes, some with atypical morphology.
A BM biopsy revealed a hypercellular marrow, moderately increased reticulin fibrosis, and features consistent with primary myelofibrosis.
Abdominal imaging showed a normal-size spleen and did not identify any sites of EMH outside of the liver.
The diagnosis of myelofibrosis was thus made, and this case demonstrated predominant tropism to a transplanted liver graft with absence of EMH elsewhere.
We would thus like to emphasize that findings of EMH in subjects with no preexisting hematologic neoplasm should warrant close follow-up and assessment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohyuddin, Ghulam Rehman& Yacoub, Abdulraheem. 2016. Primary Myelofibrosis Presenting as Extramedullary Hematopoiesis in a Transplanted Liver Graft: Case Report and Review of the Literature. Case Reports in Hematology،Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100898
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohyuddin, Ghulam Rehman& Yacoub, Abdulraheem. Primary Myelofibrosis Presenting as Extramedullary Hematopoiesis in a Transplanted Liver Graft: Case Report and Review of the Literature. Case Reports in Hematology No. 2016 (2016), pp.1-3.
https://search.emarefa.net/detail/BIM-1100898
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohyuddin, Ghulam Rehman& Yacoub, Abdulraheem. Primary Myelofibrosis Presenting as Extramedullary Hematopoiesis in a Transplanted Liver Graft: Case Report and Review of the Literature. Case Reports in Hematology. 2016. Vol. 2016, no. 2016, pp.1-3.
https://search.emarefa.net/detail/BIM-1100898
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1100898
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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