Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature
المؤلفون المشاركون
De Luca-Johnson, Javier
Ninfea, Jose I. Ruades
Pearson, Lauren
Conant, Joanna
Bryant, Ronald
Zakai, Neil A.
Tang, Mary E.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-26
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
We report the second case of ETV6-ACSL6 associated myeloproliferative neoplasm that has received a full course of imatinib therapy.
The patient was a 51-year-old previously healthy man who presented with three months of worsening dyspnea and was found to have a white count of 216,000/cmm, of which 84% were eosinophil lineage.
Cytogenetic analysis revealed a t(5;12)(q31~33;p13).
FISH was negative for PDGFRB rearrangement but additional FISH testing demonstrated an ACSL6 rearrangement.
ETV6-ACSL6 gene fusion is a rare abnormality that most often presents as a myeloproliferative-type disorder with prominent eosinophilia or basophilia.
Review of the literature yielded a total of 11 previous cases.
This gene fusion results in a t(5;12)(q31~33;p13) that mimics the t(5;12) found in ETV6-PDGFRB neoplasms.
Identification of the fusion genes involved in t(5;12) in eosinophilia-associated myeloproliferative disorders is crucial to direct an effective treatment plan.
In particular, while tyrosine kinase inhibitor therapy is effective in patients with PDGFRB rearrangement, there is little information on imatinib efficacy in patients with ETV6-ACSL6 gene fusion.
Our patient was found to be nonresponsive to imatinib therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
De Luca-Johnson, Javier& Ninfea, Jose I. Ruades& Pearson, Lauren& Conant, Joanna& Bryant, Ronald& Zakai, Neil A.…[et al.]. 2016. Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature. Case Reports in Medicine،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101171
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
De Luca-Johnson, Javier…[et al.]. Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature. Case Reports in Medicine No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101171
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
De Luca-Johnson, Javier& Ninfea, Jose I. Ruades& Pearson, Lauren& Conant, Joanna& Bryant, Ronald& Zakai, Neil A.…[et al.]. Myeloid Neoplasms with t(5;12) and ETV6-ACSL6 Gene Fusion, Potential Mimickers of Myeloid Neoplasm with PDGFRB Rearrangement: Case Report with Imatinib Therapy and Review of the Literature. Case Reports in Medicine. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101171
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1101171
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر