Cystatin C Falsely Underestimated GFR in a Critically Ill Patient with a New Diagnosis of AIDS

المؤلفون المشاركون

Brown, Caitlin S.
Kashani, Kianoush B.
Clain, Jeremy M.
Frazee, Erin N.

المصدر

Case Reports in Nephrology

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-05-17

دولة النشر

مصر

عدد الصفحات

4

التخصصات الرئيسية

الأمراض

الملخص EN

Cystatin C has been suggested to be a more accurate glomerular filtration rate (GFR) surrogate than creatinine in patients with acquired immunodeficiency syndrome (AIDS) because it is unaffected by skeletal muscle mass and dietary influences.

However, little is known about the utility of this marker for monitoring medications in the critically ill.

We describe the case of a 64-year-old female with opportunistic infections associated with a new diagnosis of AIDS.

During her course, she experienced neurologic, cardiac, and respiratory failure; yet her renal function remained preserved as indicated by an eGFR ≥ 120 mL/min and a urine output > 1 mL/kg/hr without diuresis.

The patient was treated with nephrotoxic agents; therefore cystatin C was assessed to determine if cachexia was resulting in a falsely low serum creatinine.

Cystatin C measured 1.50 mg/L which corresponded to an eGFR of 36 mL/min.

Given the >60 mL/min discrepancy, serial 8-hour urine samples were collected and a GFR > 120 mL/min was confirmed.

It is unclear why cystatin C was falsely elevated, but we hypothesize that it relates to the proinflammatory state with AIDS, opportunistic infections, and corticosteroids.

More research is needed before routine use of cystatin C in this setting can be recommended.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Brown, Caitlin S.& Kashani, Kianoush B.& Clain, Jeremy M.& Frazee, Erin N.. 2016. Cystatin C Falsely Underestimated GFR in a Critically Ill Patient with a New Diagnosis of AIDS. Case Reports in Nephrology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101235

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Brown, Caitlin S.…[et al.]. Cystatin C Falsely Underestimated GFR in a Critically Ill Patient with a New Diagnosis of AIDS. Case Reports in Nephrology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1101235

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Brown, Caitlin S.& Kashani, Kianoush B.& Clain, Jeremy M.& Frazee, Erin N.. Cystatin C Falsely Underestimated GFR in a Critically Ill Patient with a New Diagnosis of AIDS. Case Reports in Nephrology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1101235

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1101235