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Mercaptopurine Treatment in an Adult Man with Orbital and Intracranial Rosai-Dorfman Disease
المؤلفون المشاركون
Arnao, Valentina
Riolo, Marianna
Aridon, Paolo
Savettieri, Giovanni
المصدر
Case Reports in Neurological Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-20
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Rosai-Dorfmann disease (RDD) is a rare, idiopathic non-Langerhans cell histiocytosis, affecting children and young adults, that commonly presents as painless, massive cervical lymphadenopathy with fever, weight loss, and polyclonal hypergammaglobulinemia.
Cervical lymphadenopathy and extranodal involvement are the main presentations.
On the contrary, ophthalmic involvement and localisation in the central nervous system are rare.
Case Report.
An old man was admitted to our hospital for first seizure.
Brain imaging studies revealed on the left an extra-axial thickening of the dura mater with enhancement and perilesional oedema, infiltrating the sphenoorbital fissure and an isointense mass with enhancement in the orbital region with dislocation of the optic nerve.
Pathological and immunohistochemistry examination of the bioptical specimen was consistent with a diagnosis of RDD.
Treatment with levetiracetam and steroids was started obtaining only remission of seizures.
Because of the patient refusal of the surgical debulking, therapy with mercaptopurine was started, stopping disease progression.
Conclusion.
So far, very few cases of extranodal RDD with multiple CNS lesions involving the orbital region have been described.
Our case is significant because it is the first case in which the efficacy of mercaptopurine treatment has been documented in an adult patient with isolated ocular and intracranial RDD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arnao, Valentina& Riolo, Marianna& Savettieri, Giovanni& Aridon, Paolo. 2016. Mercaptopurine Treatment in an Adult Man with Orbital and Intracranial Rosai-Dorfman Disease. Case Reports in Neurological Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1101239
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arnao, Valentina…[et al.]. Mercaptopurine Treatment in an Adult Man with Orbital and Intracranial Rosai-Dorfman Disease. Case Reports in Neurological Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1101239
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arnao, Valentina& Riolo, Marianna& Savettieri, Giovanni& Aridon, Paolo. Mercaptopurine Treatment in an Adult Man with Orbital and Intracranial Rosai-Dorfman Disease. Case Reports in Neurological Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1101239
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1101239
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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