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N-Acetyl-Cysteine as Effective and Safe Chelating Agent in Metal-on-Metal Hip-Implanted Patients: Two Cases
المؤلفون المشاركون
Giampreti, A.
Lonati, Davide
Ragghianti, Benedetta
Petrolini, Valeria Margherita
Vecchio, Sarah
Locatelli, Carlo Alessandro
Ronchi, Anna
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Systemic toxicity associated with cobalt (Co) and chromium (Cr) containing metal hip alloy may result in neuropathy, cardiomyopathy, and hypothyroidism.
However clinical management concerning chelating therapy is still debated in literature.
Here are described two metal-on-metal hip-implanted patients in which N-acetyl-cysteine decreased elevated blood metal levels.
A 67-year-old male who underwent Co/Cr hip implant in September 2009 referred to our Poison Control Centre for persisting elevated Co/Cr blood levels (from March 2012 to November 2014).
After receiving oral high-dose N-acetyl-cysteine, Co/Cr blood concentrations dropped by 86% and 87% of the prechelation levels, respectively, and persisted at these latter concentrations during the following 6 months of follow-up.
An 81-year-old female who underwent Co/Cr hip implant in January 2007 referred to our Centre for detection of high Co and Cr blood levels in June 2012.
No hip revision was indicated.
After a therapy with oral high-dose N-acetyl-cysteine Co/Cr blood concentrations decreased of 45% and 24% of the prechelation levels.
Chelating agents reported in hip-implanted patients (EDTA, DMPS, and BAL) are described in few cases.
N-acetyl-cysteine may provide chelating sites for metals and in our cases reduced Co and Cr blood levels and resulted well tolerable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giampreti, A.& Lonati, Davide& Ragghianti, Benedetta& Ronchi, Anna& Petrolini, Valeria Margherita& Vecchio, Sarah…[et al.]. 2016. N-Acetyl-Cysteine as Effective and Safe Chelating Agent in Metal-on-Metal Hip-Implanted Patients: Two Cases. Case Reports in Orthopedics،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1102124
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giampreti, A.…[et al.]. N-Acetyl-Cysteine as Effective and Safe Chelating Agent in Metal-on-Metal Hip-Implanted Patients: Two Cases. Case Reports in Orthopedics No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1102124
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giampreti, A.& Lonati, Davide& Ragghianti, Benedetta& Ronchi, Anna& Petrolini, Valeria Margherita& Vecchio, Sarah…[et al.]. N-Acetyl-Cysteine as Effective and Safe Chelating Agent in Metal-on-Metal Hip-Implanted Patients: Two Cases. Case Reports in Orthopedics. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1102124
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1102124
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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