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Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics
المؤلفون المشاركون
de Leon, Jose
Wahidi, Nasratullah
Johnson, Katie M.
Brenzel, Allen
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-15
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
علم النفس
الطب البشري
الطب النفسي
الملخص EN
Intravenous haloperidol has been associated with torsades de pointes (TdP).
These two sudden deaths were probable adverse drug reactions (ADRs) following intramuscular (IM) antipsychotics.
The autopsies described lack of heart pathology and were highly compatible with the possibility of TdP in the absence of risk factors other than the accumulation of antipsychotics with a high serum peak after the last injection, leading to death within hours.
The first case was a 27-year-old African-American male with schizophrenia but no medical issues.
His death was probably caused by repeated IM haloperidol injections of 10 mg (totaling 35 mg in 2 days).
The second case involves a 42-year-old African-American female with metabolic syndrome.
Her probable cause of death was the last ziprasidone IM injection of 20 mg in addition to (1) three extra haloperidol doses (2 hours before the ziprasidone injection, 5 mg oral haloperidol; approximately 21 hours earlier, 5 mg oral haloperidol; and 2 days prior, one 10 mg IM haloperidol injection), (2) 10 mg/day of scheduled oral haloperidol for 6 days before death, and (3) a long-acting paliperidone injection of 156 mg 18 days before death.
The study of haloperidol glucuronidation and its impairment in some African-Americans is urgently recommended.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wahidi, Nasratullah& Johnson, Katie M.& Brenzel, Allen& de Leon, Jose. 2016. Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics. Case Reports in Psychiatry،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1102518
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wahidi, Nasratullah…[et al.]. Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics. Case Reports in Psychiatry No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1102518
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wahidi, Nasratullah& Johnson, Katie M.& Brenzel, Allen& de Leon, Jose. Two Sudden and Unexpected Deaths of Patients with Schizophrenia Associated with Intramuscular Injections of Antipsychotics and Practice Guidelines to Limit the Use of High Doses of Intramuscular Antipsychotics. Case Reports in Psychiatry. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1102518
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1102518
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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