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Combination Immunosuppressive Therapy Including Rituximab for Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adult-Onset Still’s Disease
المؤلفون المشاركون
Schäfer, Eva Johanna
Jung, Wolfram
Korsten, Peter
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-28
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Hemophagocytic lymphopcytosis (HLH) is a life-threatening condition.
It can occur either as primary form with genetic defects or secondary to other conditions, such as hematological or autoimmune diseases.
Certain triggering factors can predispose individuals to the development of HLH.
We report the case of a 25-year-old male patient who was diagnosed with HLH in the context of adult-onset Still’s disease (AOSD) during a primary infection with Epstein-Barr virus (EBV).
During therapy with anakinra and dexamethasone, he was still symptomatic with high-spiking fevers, arthralgia, and sore throat.
His laboratory values showed high levels of ferritin and C-reactive protein.
His condition improved after the addition of rituximab and cyclosporine to his immunosuppressive regimen with prednisolone and anakinra.
This combination therapy led to a sustained clinical and serological remission of his condition.
While rituximab has been used successfully for HLH in the context of EBV-associated lymphoma, its use in autoimmune diseases is uncommon.
We hypothesize that the development of HLH was triggered by a primary EBV infection and that rituximab led to elimination of EBV-infected B-cells, while cyclosporine ameliorated the cytokine excess.
We therefore propose that this combination immunosuppressive therapy might be successfully used in HLH occurring in the context of autoimmune diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schäfer, Eva Johanna& Jung, Wolfram& Korsten, Peter. 2016. Combination Immunosuppressive Therapy Including Rituximab for Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adult-Onset Still’s Disease. Case Reports in Rheumatology،Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1102674
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schäfer, Eva Johanna…[et al.]. Combination Immunosuppressive Therapy Including Rituximab for Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adult-Onset Still’s Disease. Case Reports in Rheumatology No. 2016 (2016), pp.1-4.
https://search.emarefa.net/detail/BIM-1102674
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schäfer, Eva Johanna& Jung, Wolfram& Korsten, Peter. Combination Immunosuppressive Therapy Including Rituximab for Epstein-Barr Virus-Associated Hemophagocytic Lymphohistiocytosis in Adult-Onset Still’s Disease. Case Reports in Rheumatology. 2016. Vol. 2016, no. 2016, pp.1-4.
https://search.emarefa.net/detail/BIM-1102674
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1102674
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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