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Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK
المؤلفون المشاركون
Yin, Lei-Miao
Han, Xiao-Jie
Duan, Ting-Ting
Xu, Yu-Dong
Ulloa, Luis
Yang, Yong Qing
Wang, Yu
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Asthma is a disease with a core abnormality in airway smooth muscle function, and the proliferation of airway smooth muscle cells (ASMCs) plays a pivotal role in asthma airway remodeling.
Our previous study showed that S100A9 (S100 calcium-binding protein A9; 400 and 800 ng/mL) significantly inhibited rat ASMCs proliferation at 48 h, and 50–800 ng/mL S100A9 (50, 100, 200, 400, and 800 ng/mL) also induced a lasting effect by significantly inhibiting rat ASMCs proliferation at 72 h in a dose-dependent manner.
However, the intracellular effects of S100A9 on ASMCs proliferation remain unknown.
Methods.
Rat ASMCs with stable S100A9 knockdown were generated using short hairpin RNA.
The effects of decreased S100A9 expression on cellular proliferation, the production of reactive oxygen species (ROS), and p38 MAPK pathway protein expression were examined.
Results.
Decreased intracellular S100A9 expression significantly promoted platelet-derived growth factor-induced rat ASMCs proliferation and increased ROS production.
The antioxidative agent N-acetylcysteine significantly inhibited rat ASMCs proliferation.
Western blot results showed that the decreased intracellular S100A9 expression significantly inhibited p38 MAPK phosphorylation.
Conclusion.
Decreased S100A9 expression promoted rat ASMCs proliferation by stimulating ROS generation and inhibiting p38 MAPK.
Our study may provide novel insights into the regulation of asthma airway remodeling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yin, Lei-Miao& Han, Xiao-Jie& Duan, Ting-Ting& Xu, Yu-Dong& Wang, Yu& Ulloa, Luis…[et al.]. 2016. Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK. Canadian Respiratory Journal،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103164
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yin, Lei-Miao…[et al.]. Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK. Canadian Respiratory Journal No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103164
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yin, Lei-Miao& Han, Xiao-Jie& Duan, Ting-Ting& Xu, Yu-Dong& Wang, Yu& Ulloa, Luis…[et al.]. Decreased S100A9 Expression Promoted Rat Airway Smooth Muscle Cell Proliferation by Stimulating ROS Generation and Inhibiting p38 MAPK. Canadian Respiratory Journal. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103164
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103164
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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