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Intermittent Courses of Corticosteroids Also Present a Risk for Pneumocystis Pneumonia in Non-HIV Patients
المؤلفون المشاركون
Calero-Bernal, Maria L.
Martin-Garrido, Isabel
Donazar-Ezcurra, Mikel
Limper, Andrew H.
Carmona, Eva M.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Introduction.
Pneumocystis pneumonia (PCP) is rising in the non-HIV population and associates with higher morbidity and mortality.
The aggressive immunosuppressive regimens, as well as the lack of stablished guidelines for chemoprophylaxis, are likely contributors to this increased incidence.
Herein, we have explored the underlying conditions, immunosuppressive therapies, and clinical outcomes of PCP in HIV-negative patients.
Methods.
Retrospective analysis of PCP in HIV-negative patients at Mayo Clinic from 2006–2010.
The underlying condition, immunosuppressive therapies, coinfection, and clinical course were determined.
PCP diagnosis required symptoms of pneumonia and identification of the organisms by visualization or by a real-time polymerase chain reaction.
Results.
A total of 128 cases of PCP were identified during the study period.
Hematological malignancies were the predisposing condition for 50% of the patients.
While 87% had received corticosteroids or other immunosuppressive therapies for >4 weeks prior to the diagnosis, only 7 were receiving PCP prophylaxis.
Up to 43% of patients were not on daily steroids.
Sixty-seven patients needed Intensive Care Unit (ICU) and 53 received mechanical ventilation.
The mortality for those patients requiring ICU was 40%.
Conclusions.
PCP diagnosis in the HIV-negative population requires a high level of suspicion even if patients are not receiving daily corticosteroids.
Mortality remains high despite adequate treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Calero-Bernal, Maria L.& Martin-Garrido, Isabel& Donazar-Ezcurra, Mikel& Limper, Andrew H.& Carmona, Eva M.. 2016. Intermittent Courses of Corticosteroids Also Present a Risk for Pneumocystis Pneumonia in Non-HIV Patients. Canadian Respiratory Journal،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103172
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Calero-Bernal, Maria L.…[et al.]. Intermittent Courses of Corticosteroids Also Present a Risk for Pneumocystis Pneumonia in Non-HIV Patients. Canadian Respiratory Journal No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103172
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Calero-Bernal, Maria L.& Martin-Garrido, Isabel& Donazar-Ezcurra, Mikel& Limper, Andrew H.& Carmona, Eva M.. Intermittent Courses of Corticosteroids Also Present a Risk for Pneumocystis Pneumonia in Non-HIV Patients. Canadian Respiratory Journal. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103172
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103172
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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