Clinical Significance of the Relationship between Progression-Free Survival or Postprogression Survival and Overall Survival in Patients with Extensive Disease-Small-Cell Lung Cancer Treated with Carboplatin plus Etoposide
المؤلفون المشاركون
Yamada, Masanobu
Imai, Hisao
Mori, Keita
Watase, Nodoka
Fujimoto, Sakae
Kaira, Kyoichi
Minato, Koichi
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The effects of first-line chemotherapy on overall survival (OS) might be confounded by subsequent therapies in patients with small-cell lung cancer (SCLC).
Therefore, by using individual-level data, we aimed to determine the relationships between progression-free survival (PFS) or postprogression survival (PPS) and OS after first-line chemotherapies in patients with extensive disease-SCLC (ED-SCLC) treated with carboplatin plus etoposide.
Methods.
Between July 1998 and December 2014, we analyzed 63 cases of patients with ED-SCLC who were treated with carboplatin and etoposide as first-line chemotherapy.
The relationships of PFS and PPS with OS were analyzed at the individual level.
Results.
Spearman rank correlation analysis and linear regression analysis showed that PPS was strongly correlated with OS ( r = 0.90 , p < 0.05 , and R 2 = 0.71 ) and PFS was moderately correlated with OS ( r = 0.72 , p < 0.05 , and R 2 = 0.62 ).
Type of relapse (refractory/sensitive) and the number of regimens administered after disease progression after the first-line chemotherapy were both significantly associated with PPS ( p < 0.05 ).
Conclusions.
PPS has a stronger relationship with OS than does PFS in ED-SCLC patients who have received first-line chemotherapy.
These results suggest that treatments administered after first-line chemotherapy affect the OS of ED-SCLC patients treated with carboplatin plus etoposide.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Imai, Hisao& Mori, Keita& Watase, Nodoka& Fujimoto, Sakae& Kaira, Kyoichi& Yamada, Masanobu…[et al.]. 2016. Clinical Significance of the Relationship between Progression-Free Survival or Postprogression Survival and Overall Survival in Patients with Extensive Disease-Small-Cell Lung Cancer Treated with Carboplatin plus Etoposide. Canadian Respiratory Journal،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103211
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Imai, Hisao…[et al.]. Clinical Significance of the Relationship between Progression-Free Survival or Postprogression Survival and Overall Survival in Patients with Extensive Disease-Small-Cell Lung Cancer Treated with Carboplatin plus Etoposide. Canadian Respiratory Journal No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103211
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Imai, Hisao& Mori, Keita& Watase, Nodoka& Fujimoto, Sakae& Kaira, Kyoichi& Yamada, Masanobu…[et al.]. Clinical Significance of the Relationship between Progression-Free Survival or Postprogression Survival and Overall Survival in Patients with Extensive Disease-Small-Cell Lung Cancer Treated with Carboplatin plus Etoposide. Canadian Respiratory Journal. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103211
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103211
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر