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Assessment of the Protective Role of Prenatal Zinc versus Insulin Supplementation on Fetal Cardiac Damage Induced by Maternal Diabetes in Rat Using Caspase-3 and KI67 Immunohistochemical Stains
المؤلفون المشاركون
Shams, Ahmed S.
Mohammed, Mona H.
Loka, Mona M.
Abdel Rahman, Gamal M.
المصدر
Cardiology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Maternal diabetes mellitus (DM) affects early organogenesis.
Metabolic disorders of DM are associated with a depleted zinc status.
This study evaluated the effect of maternal DM on cardiac development of rat fetuses and protective roles of prenatal zinc versus insulin supplementation.
Pregnant rats were divided into 4 groups ((I) control, (II) STZ-induced DM, (III) STZ-induced DM treated with Zn, and (IV) STZ induced DM treated with insulin), all sacrificed on GD 20.
Fetal heart weight of diabetic rats showed significant decrease compared to controls ( P < 0.05 ).
H&E stained section of controls had normal appearance of the myocardium, compared to diabetics that showed myocardial disarray with characteristic degenerative changes.
Sections of zinc treated group showed restored architecture of normal myofibrils with minimal degenerative changes, while those of insulin treated group show partial restoration of the normal architecture of cardiomyocytes with focal improvement of cardiac tissue.
Caspase-3 immunostained slides showed positive cytoplasmic immunoreactivity in diabetic group.
But KI67 immunostained slides revealed negative nuclear immunoreaction in diabetics.
We observed that gestational diabetes was associated with increased risk of fetal myocardial damage that might be caused by increased apoptotic level.
Treating diabetic pregnant subjects with zinc and insulin was associated with improvement in myocardial integrity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shams, Ahmed S.& Mohammed, Mona H.& Loka, Mona M.& Abdel Rahman, Gamal M.. 2016. Assessment of the Protective Role of Prenatal Zinc versus Insulin Supplementation on Fetal Cardiac Damage Induced by Maternal Diabetes in Rat Using Caspase-3 and KI67 Immunohistochemical Stains. Cardiology Research and Practice،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103299
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shams, Ahmed S.…[et al.]. Assessment of the Protective Role of Prenatal Zinc versus Insulin Supplementation on Fetal Cardiac Damage Induced by Maternal Diabetes in Rat Using Caspase-3 and KI67 Immunohistochemical Stains. Cardiology Research and Practice No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1103299
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shams, Ahmed S.& Mohammed, Mona H.& Loka, Mona M.& Abdel Rahman, Gamal M.. Assessment of the Protective Role of Prenatal Zinc versus Insulin Supplementation on Fetal Cardiac Damage Induced by Maternal Diabetes in Rat Using Caspase-3 and KI67 Immunohistochemical Stains. Cardiology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1103299
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103299
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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