IL-4 Gene Polymorphism May Contribute to an Increased Risk of Atopic Dermatitis in Children
المؤلفون المشاركون
Shang, Hong
Cao, Xiu-Li
Wan, Yu-Jie
Meng, Jin
Guo, Lu-Hong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This study aimed to elucidate the associations between interleukin-4 (IL-4) single nucleotide polymorphisms (SNPs), 590C/T and 589C/T, serum IL-4 levels, and atopic dermatitis (AD) in children.
Methods.
A total of 82 children with AD were randomly selected as the case group and divided into mild group (15 cases), moderate group (46 cases), and severe group (21 cases).
Additionally, 100 healthy children were selected as the control group.
Genotype frequencies of IL-4 SNPs were detected by PCR-RFLP.
Serum IL-4 levels were measured by ELISA.
Results.
Significant differences were shown in genotype distributions and allele frequencies of 589C/T and allele frequencies of 590C/T (all P<0.05).
Serum IL-4 levels in the mild, moderate, and severe groups were significantly higher than those in the control group; significant differences were found among these three groups with increased severity of AD.
Serum IL-4 levels of heterozygote and mutant homozygote carriers in the mild, moderate, and severe groups were higher than wild homozygote carriers in those three groups and the control group (all P<0.05).
Conclusion.
590T and 589T alleles of IL-4 gene may be associated with high levels of serum IL-4, which may increase the risk of AD in children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shang, Hong& Cao, Xiu-Li& Wan, Yu-Jie& Meng, Jin& Guo, Lu-Hong. 2016. IL-4 Gene Polymorphism May Contribute to an Increased Risk of Atopic Dermatitis in Children. Disease Markers،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103651
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shang, Hong…[et al.]. IL-4 Gene Polymorphism May Contribute to an Increased Risk of Atopic Dermatitis in Children. Disease Markers No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103651
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shang, Hong& Cao, Xiu-Li& Wan, Yu-Jie& Meng, Jin& Guo, Lu-Hong. IL-4 Gene Polymorphism May Contribute to an Increased Risk of Atopic Dermatitis in Children. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103651
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103651
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر