Predictive Value of Plasma MicroRNA-216ab in the Diagnosis of Esophageal Squamous Cell Carcinoma
المؤلفون المشاركون
Dong, Shuling
Yin, Huiqing
Dong, Cuicui
Sun, Kaiyan
Lv, Pin
Meng, Weiwei
Ming, Liang
He, Fucheng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Esophageal squamous cell carcinoma (ESCC) is a common human malignancy with poor survival, which was usually diagnosed at an advanced stage.
MicroRNAs (miRNAs), a class of single stranded noncoding RNAs with only 17–25 ribonucleotides, were demonstrated to play an important role in lots of cancers.
In the recent years, increasing evidence revealed that circulating miRNAs exhibited great potential in the diagnosis of various types of cancers.
The present study was designed to evaluate the diagnostic value of plasma miRNA-216a/b for ESCC.
Our results showed that the expression level of plasma miRNA-216a/b was significantly lower in ESCC patients compared with that of healthy controls.
The receiver operating characteristic (ROC) curve analysis yielded an area under the ROC curve (AUC) value of 0.877 [95% CI (confidence interval): 0.818–0.922] for miRNA-216a and 0.756 (95% CI: 0.685–0.819) for miRNA-216b.
Clinical data indicated that plasma miRNA-216a/b were inversely correlated with lymph node metastasis and TNM stage.
Additionally, the plasma miRNA-216b expression level was significantly upregulated in postoperative samples compared to preoperative samples.
Our study, for the first time, demonstrated that plasma miRNA-216a/b might serve as potential biomarkers for the diagnosis of ESCC and dysregulation of miRNA-216a/b might be involved in the progression of ESCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dong, Shuling& Yin, Huiqing& Dong, Cuicui& Sun, Kaiyan& Lv, Pin& Meng, Weiwei…[et al.]. 2016. Predictive Value of Plasma MicroRNA-216ab in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103663
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dong, Shuling…[et al.]. Predictive Value of Plasma MicroRNA-216ab in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103663
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dong, Shuling& Yin, Huiqing& Dong, Cuicui& Sun, Kaiyan& Lv, Pin& Meng, Weiwei…[et al.]. Predictive Value of Plasma MicroRNA-216ab in the Diagnosis of Esophageal Squamous Cell Carcinoma. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103663
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103663
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر