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Pathway Analysis Based on Attractor and Cross Talk in Colon Cancer
المؤلفون المشاركون
Liu, Yanxia
Wang, Lin
Wang, Bingping
Yue, Meng
Cheng, Yufeng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Colon cancer is the third and second most common cancer form in men and women worldwide.
It is generally accepted that colon cancer mainly results from diet.
The aim of this study was to identify core pathways which elucidated the molecular mechanisms in colon cancer.
The microarray data of E-GEOD-44861 was downloaded from ArrayExpress database.
All human pathways were obtained from Kyoto Encyclopedia of Genes and Genomes database.
In total, 135 differential expressed genes (DEG) were identified using Linear Models for Microarray Data package.
Differential pathways were identified with the method of attractor after overlapping with DEG.
Pathway cross talk network (PCN) was constructed by combining protein-protein interactions and differential pathways.
Cross talks of all pathways were obtained in PCN.
There were 65 pathways with RankProd (RP) values < 0.05 and 16 pathways with Impact Factors (IF) values > 100.
Five pathways were satisfied with P value < 0.05, RP values < 0.05, and IF values > 100, which were considered to be the most important pathways in colon cancer.
In conclusion, the five pathways were identified in the center status of colon cancer, which may contribute to understanding the mechanism and development of colon cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Yanxia& Wang, Lin& Wang, Bingping& Yue, Meng& Cheng, Yufeng. 2016. Pathway Analysis Based on Attractor and Cross Talk in Colon Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103674
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Yanxia…[et al.]. Pathway Analysis Based on Attractor and Cross Talk in Colon Cancer. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103674
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Yanxia& Wang, Lin& Wang, Bingping& Yue, Meng& Cheng, Yufeng. Pathway Analysis Based on Attractor and Cross Talk in Colon Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103674
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103674
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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