Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients
المؤلفون المشاركون
Granieri, E.
Kostic, Vladimir S.
Fainardi, Enrico
Trentini, Alessandro
Manfrinato, Maria Cristina
Tamborino, Carmine
Hanau, Stefania
Volta, Carlo Alberto
Baldi, Eleonora
Drulovic, Jelena
Dallocchio, Franco
Bellini, Tiziana
Dujmovic, Irena
Castellazzi, Massimiliano
Cervellati, Carlo
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Matrix Metalloproteases (MMPs) and cytokines have been involved in the pathogenesis of multiple sclerosis (MS).
However, no studies have still explored the possible associations between the two families of molecules.
The present study aimed to evaluate the contribution of active MMP-9, active MMP-2, interleukin- (IL-) 17, IL-18, IL-23, and monocyte chemotactic proteins-3 to the pathogenesis of MS and the possible interconnections between MMPs and cytokines.
The proteins were determined in the serum and cerebrospinal fluid (CSF) of 89 MS patients and 92 other neurological disorders (OND) controls.
Serum active MMP-9 was increased in MS patients and OND controls compared to healthy subjects ( p < 0.001 and p < 0.01 , resp.), whereas active MMP-2 and ILs did not change.
CSF MMP-9, but not MMP-2 or ILs, was selectively elevated in MS compared to OND ( p < 0.01 ).
Regarding the MMPs and cytokines intercorrelations, we found a significant association between CSF active MMP-2 and IL-18 ( r = 0.3 , p < 0.05 ), while MMP-9 did not show any associations with the cytokines examined.
Collectively, our results suggest that active MMP-9, but not ILs, might be a surrogate marker for MS.
In addition, interleukins and MMPs might synergistically cooperate in MS, indicating them as potential partners in the disease process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Trentini, Alessandro& Castellazzi, Massimiliano& Cervellati, Carlo& Manfrinato, Maria Cristina& Tamborino, Carmine& Hanau, Stefania…[et al.]. 2016. Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103690
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Trentini, Alessandro…[et al.]. Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103690
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Trentini, Alessandro& Castellazzi, Massimiliano& Cervellati, Carlo& Manfrinato, Maria Cristina& Tamborino, Carmine& Hanau, Stefania…[et al.]. Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103690
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103690
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر