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Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect
المؤلفون المشاركون
Haddad, Mohamed
Knani, Ines
Bouzidi, Hsan
Berriche, Olfa
Kerkeni, Mohsen
Hammami, Mohamed
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Metabolic syndrome (MetS) is considered one of the most important public health problems.
Several and controversial studies showed that the role of advanced glycation end products (AGEs) and their receptor in the development of metabolic syndrome and therapeutic pathways is still unsolved.
We have investigated whether plasma pentosidine, carboxymethyl-lysine (CML), and soluble receptor for advanced glycation end products (sRAGE) levels were increased in patients with MetS and the effect of metformin in plasma levels of pentosidine, CML, and sRAGE.
80 control subjects and 86 patients were included in this study.
Pentosidine, CML, and sRAGE were measured in plasma by enzyme-linked immunosorbent assay (ELISA).
Plasma pentosidine, CML, and sRAGE levels were significantly increased in patients compared to control subjects (P<0.001, P<0.001, and P=0.014, resp.).
Plasma levels of pentosidine were significantly decreased in patients who received metformin compared to untreated patients (P=0.01).
However, there was no significant difference between patients treated with metformin and untreated patients in plasma CML levels.
Plasma levels of sRAGE were significantly increased in patients who received metformin and ACE inhibitors (P<0.001 and P=0.002, resp.).
However, in a multiple stepwise regression analysis, pentosidine, sRAGE, and drugs treatments were not independently associated.
Patients with metabolic syndrome showed increased levels of AGEs such as pentosidine and CML.
Metformin treatment showed a decreased level of pentosidine but not of CML.
Therapeutic pathways of AGEs development should be taken into account and further experimental and in vitro studies merit for advanced research.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haddad, Mohamed& Knani, Ines& Bouzidi, Hsan& Berriche, Olfa& Hammami, Mohamed& Kerkeni, Mohsen. 2016. Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect. Disease Markers،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103738
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haddad, Mohamed…[et al.]. Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect. Disease Markers No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103738
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haddad, Mohamed& Knani, Ines& Bouzidi, Hsan& Berriche, Olfa& Hammami, Mohamed& Kerkeni, Mohsen. Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103738
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103738
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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