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Circulating Glutamate and Taurine Levels Are Associated with the Generation of Reactive Oxygen Species in Paroxysmal Atrial Fibrillation
المؤلفون المشاركون
Takano, Shintaro
Fujibayashi, Kousuke
Fujioka, Nakaba
Ueno, Ei-ichi
Wakasa, Minoru
Kawai, Yasuyuki
Kajinami, Kouji
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Atrial fibrillation (AF) is the most common cardiac arrhythmia, but its proarrhythmic mechanism remains to be elucidated.
Glutamate (Glu) and taurine (Tau) are present in the myocardium at substantially higher concentrations than in the plasma, suggesting their active role in myocardium.
Here, we tested the hypothesis that the metabolism of Glu and Tau is altered in association with the generation of reactive oxygen species (ROS) in patients with AF.
Fifty patients with paroxysmal AF and 50 control subjects without a history of AF were consecutively enrolled.
Circulating Glu and Tau levels were measured and correlations between Glu/Tau and ROS levels were examined.
Glu/Tau content was significantly higher in patients with AF versus controls (Glu: 79.2 ± 23.9 versus 60.5 ± 25.2 nmol/L; Tau: 78.8 ± 19.8 versus 68.5 ± 20.8 nmol/L; mean ± standard deviation (SD), p < 0.001 for both).
Glu/Tau levels also showed an independent association with AF by multiple logistic regression analysis.
Glu and Tau levels both showed significant positive associations with plasma hydroperoxide concentrations.
These data suggest a novel pathophysiological role of Glu and Tau in association with ROS production in paroxysmal AF, providing new insights into the elevated amino acid content in cardiac disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takano, Shintaro& Fujibayashi, Kousuke& Fujioka, Nakaba& Ueno, Ei-ichi& Wakasa, Minoru& Kawai, Yasuyuki…[et al.]. 2016. Circulating Glutamate and Taurine Levels Are Associated with the Generation of Reactive Oxygen Species in Paroxysmal Atrial Fibrillation. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103770
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takano, Shintaro…[et al.]. Circulating Glutamate and Taurine Levels Are Associated with the Generation of Reactive Oxygen Species in Paroxysmal Atrial Fibrillation. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103770
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takano, Shintaro& Fujibayashi, Kousuke& Fujioka, Nakaba& Ueno, Ei-ichi& Wakasa, Minoru& Kawai, Yasuyuki…[et al.]. Circulating Glutamate and Taurine Levels Are Associated with the Generation of Reactive Oxygen Species in Paroxysmal Atrial Fibrillation. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103770
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103770
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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