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Contribution of BRCA1 and BRCA2 Germline Mutations to Early Algerian Breast Cancer
المؤلفون المشاركون
Henouda, Sarra
Bensalem, Assia
Reggad, Rym
Serrar, Nedda
Rouabah, Leila
Pujol, Pascal
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Breast cancer is the most common female malignancy and the leading cancer mortality cause among Algerian women.
Germline mutations in the BRCA1 and BRCA2 genes in patients with early-onset breast cancer have not been clearly identified within the Algerian population.
It is necessary to study the BRCA1/2 genes involvement in the Algerian breast cancer occurrence.
We performed this study to define germline mutations in BRCA1/2 and their implication in breast cancer among young women from eastern Algeria diagnosed or treated with primary invasive breast cancer at the age of 40 or less who were referred to Anti-Cancer Center of Setif, Algeria.
Case series were unselected for family history.
Eight distinct pathogenic mutations were identified in eight unrelated families.
Three deleterious mutations and one large genomic rearrangement involving deletion of exon 2 were found in BRCA1 gene.
In addition, four mutations within the BRCA2 gene and one large genomic rearrangement were identified.
Novel mutation was found among Algerian population.
Moreover, five variants of uncertain clinical significance and favor polymorphisms were identified.
Our data suggest that BRCA1/2 mutations are responsible for a significant proportion of breast cancer in Algerian young women.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Henouda, Sarra& Bensalem, Assia& Reggad, Rym& Serrar, Nedda& Rouabah, Leila& Pujol, Pascal. 2016. Contribution of BRCA1 and BRCA2 Germline Mutations to Early Algerian Breast Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103775
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Henouda, Sarra…[et al.]. Contribution of BRCA1 and BRCA2 Germline Mutations to Early Algerian Breast Cancer. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103775
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Henouda, Sarra& Bensalem, Assia& Reggad, Rym& Serrar, Nedda& Rouabah, Leila& Pujol, Pascal. Contribution of BRCA1 and BRCA2 Germline Mutations to Early Algerian Breast Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103775
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103775
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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