Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer
المؤلفون المشاركون
Chen, Chuan-Mu
Cheng, Ya-Wen
Chen, I-Chien
Lee, Kuen-Haur
Hsu, Ying-Hua
Wang, Wei-Ran
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Aims.
Cancer cells use the indoleamine 2,3-dioxygenase 1 (IDO1) pathway to suppress the host’s immune response in order to facilitate survival, growth, invasion, and metastasis of malignant cells.
Higher IDO1 expression was shown to be involved in colorectal cancer (CRC) progression and to be correlated with impaired clinical outcome.
However, the potential correlation between the expression of IDO1 in a CRC population with a low mutation rate of the APC gene remains unknown.
Material and Methods.
Tissues and blood samples were collected from 192 CRC patients.
The expressions of IDO1, tryptophan 2,3-dioxygenase (TDO2), and beta-catenin proteins were analyzed by immunohistochemistry.
Microsatellite instability (MSI) was determined by PCR amplification of microsatellite loci.
Results.
The results showed that high IDO1 or TDO2 protein expression was associated with characteristics of more aggressive phenotypes of CRC.
For the first time, they also revealed a positive correlation between the abnormal expression of beta-catenin and IDO1 or TDO2 proteins in a CRC population with a low mutation rate of APC.
Conclusion.
We concluded that an IDO1-regulated molecular pathway led to abnormal expression of beta-catenin in the nucleus/cytoplasm of CRC patients with low mutation rate of APC, making IDO1 an interesting target for immunotherapy in CRC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, I-Chien& Lee, Kuen-Haur& Hsu, Ying-Hua& Wang, Wei-Ran& Chen, Chuan-Mu& Cheng, Ya-Wen. 2016. Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer. Disease Markers،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103782
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, I-Chien…[et al.]. Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer. Disease Markers No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1103782
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, I-Chien& Lee, Kuen-Haur& Hsu, Ying-Hua& Wang, Wei-Ran& Chen, Chuan-Mu& Cheng, Ya-Wen. Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1103782
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103782
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر