Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma
المؤلفون المشاركون
Pryczynicz, Anna
Kemona, Andrzej
Jakubowska, Katarzyna
Januszewska, Joanna
Sidorkiewicz, Iwona
Niewiński, Andrzej
Lewczuk, Łukasz
Kędra, Bogusław
Guzińska-Ustymowicz, Katarzyna
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal disease, usually diagnosed in an advanced stage which gives a slight chance of recovery.
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that participate in tissue remodeling and stimulate neovascularization and inflammatory response.
The aim of the study was to evaluate the expression of MMP-2, MMP-7, and MMP-9 in normal ducts, tumor pancreatic adenocarcinoma cells, and peritumoral stroma in correlation with clinicohistopathological parameters.
The study material was obtained from 29 patients with pancreatic ductal adenocarcinoma.
The expressions of MMP-2, MMP-7, and MMP-9 were performed by immunohistochemical technique.
Microvessel density (MVD) was visualized by special immunostaining.
The expressions of MMP-2, MMP-7, and MMP-9 were mainly observed in tumor cells and peritumoral stroma.
MMP-2 expression in cancer cells was correlated with female gender, stronger inflammation, and histopathological type of cancer ( R = 0.460 , p = 0.013 ; R = 0.690 , p = 0.0001 ; R = - 0.440 , p = 0.005 , resp.).
The expression of MMP-7 in tumor cells was found to positively correlate with the presence of necrosis and negatively correlate with MVD ( R = 0.402 , p = 0.031 ; R = - 0.682 , p = 0.000 ).
We also showed that positive MMP-9 expression in tumor cells was associated with MVD ( R = 0.368 , p = 0.084 ); however, it was not statistically significant.
Our results demonstrate that MMP-2, MMP-7, and MMP-9 expressions correlate with various morphological features of the PDAC tumor such as inflammation, necrosis, and formation of the new blood vessels.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jakubowska, Katarzyna& Pryczynicz, Anna& Januszewska, Joanna& Sidorkiewicz, Iwona& Kemona, Andrzej& Niewiński, Andrzej…[et al.]. 2016. Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma. Disease Markers،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103830
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jakubowska, Katarzyna…[et al.]. Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma. Disease Markers No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103830
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jakubowska, Katarzyna& Pryczynicz, Anna& Januszewska, Joanna& Sidorkiewicz, Iwona& Kemona, Andrzej& Niewiński, Andrzej…[et al.]. Expressions of Matrix Metalloproteinases 2, 7, and 9 in Carcinogenesis of Pancreatic Ductal Adenocarcinoma. Disease Markers. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103830
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103830
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر