Cutaneous Side Effects of BRAF Inhibitors in Advanced Melanoma: Review of the Literature
المؤلفون المشاركون
Gönül, Müzeyyen
Gençler, Bilgen
المصدر
Dermatology Research and Practice
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The incidence of melanoma has recently been increasing.
BRAF mutations have been found in 40–60% of melanomas.
The increased activity of BRAF V600E leads to the activation of downstream signaling through the mitogen-activated protein kinase (MAPK) pathway, which plays a key role as a regulator of cell growth, differentiation, and survival.
The use of BRAF inhibitors in metastatic melanoma with BRAF mutation ensures clinical improvement of the disease.
Vemurafenib and dabrafenib are two selective BRAF inhibitors approved by the Food and Drug Administration (FDA).
Both drugs are well tolerated and successfully used in clinical practice.
However, some adverse reactions have been reported in patients in the course of treatment.
Cutaneous side effects are the most common adverse events among them with a broad spectrum.
Both the case reports and several original clinical trials reported cutaneous reactions during the treatment with BRAF inhibitors.
In this review, the common cutaneous side effects of BRAF inhibitors in the treatment of metastatic melanoma with BRAF V600E mutation were reviewed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gençler, Bilgen& Gönül, Müzeyyen. 2016. Cutaneous Side Effects of BRAF Inhibitors in Advanced Melanoma: Review of the Literature. Dermatology Research and Practice،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103839
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gençler, Bilgen& Gönül, Müzeyyen. Cutaneous Side Effects of BRAF Inhibitors in Advanced Melanoma: Review of the Literature. Dermatology Research and Practice No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1103839
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gençler, Bilgen& Gönül, Müzeyyen. Cutaneous Side Effects of BRAF Inhibitors in Advanced Melanoma: Review of the Literature. Dermatology Research and Practice. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1103839
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103839
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر