Inhibitory Effect of Yongdamsagan-Tang Water Extract, a Traditional Herbal Formula, on Testosterone-Induced Benign Prostatic Hyperplasia in Rats
المؤلفون المشاركون
Shin, Hyeun-Kyoo
Seo, Chang-Seob
Jeon, Woo-Young
Park, Eunsook
Lee, Nari
Lee, Mee-Young
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Yongdamsagan-tang, a traditional herbal formula, is used widely for the treatment of inflammation and viral diseases.
In this study, we investigated whether Yongdamsagan-tang water extract (YSTE) affects testosterone propionate- (TP-) induced benign prostatic hyperplasia (BPH) in a rat model.
To induce BPH, rats were injected subcutaneously with 10 mg/kg of TP every day.
YSTE was administrated daily by oral gavage at doses of 200 and 500 mg/kg along with the TP injection.
After 4 weeks, prostates were collected, weighed, and analyzed.
The relative prostrate weight was significantly lower in both YSTE groups (200 and 500 mg/kg/day) compared with the TP-induced BPH group.
YSTE administration reduced the expression of proliferation markers PCNA, cyclin D1, and Ki-67 and the histological abnormalities observed in the prostate in TP-induced BPH rats.
YSTE attenuated the increase in the TP-induced androgen concentration in the prostate.
The YSTE groups also showed decreased lipid peroxidation and increased glutathione reductase activity in the prostate.
These findings suggest that YSTE effectively prevented the development of TP-induced BPH in rats through antiproliferative and antioxidative activities and might be useful in the clinical treatment of BPH.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Park, Eunsook& Lee, Mee-Young& Jeon, Woo-Young& Lee, Nari& Seo, Chang-Seob& Shin, Hyeun-Kyoo. 2016. Inhibitory Effect of Yongdamsagan-Tang Water Extract, a Traditional Herbal Formula, on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103904
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Park, Eunsook…[et al.]. Inhibitory Effect of Yongdamsagan-Tang Water Extract, a Traditional Herbal Formula, on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1103904
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Park, Eunsook& Lee, Mee-Young& Jeon, Woo-Young& Lee, Nari& Seo, Chang-Seob& Shin, Hyeun-Kyoo. Inhibitory Effect of Yongdamsagan-Tang Water Extract, a Traditional Herbal Formula, on Testosterone-Induced Benign Prostatic Hyperplasia in Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1103904
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103904
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر