In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine
المؤلفون المشاركون
Ghareeb, Doaa A.
Mahmoud, Mohammad Ahmad
Sahyoun, Heba Abdelghany
Elshehawy, Ashraf Abdelhamed
Elsayed, Mohammad Mohammad
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
This research was conducted to investigate if there is a relation between insulin resistance incidence and inhibition of interferon gamma production or not.
Firstly, insulin resistance was induced by high fat diet (HFD) intake for 6 weeks.
Secondly, berberine was used as protective/curative compound for insulin resistance.
Results revealed that feeding rats HFD for 6 weeks developed features of insulin resistance (IR) syndrome.
These features presented in increased body weight, hyperglycemia, hyperinsulinemia, hypercholesterolemia (with increased LDL-cholesterol and decreased HDL-cholesterol), and hypertriglyceridemia.
Level of antioxidant enzymes in HFD group was higher than in normal one.
Also there was an increasing in level of proinflammatory cytokines as interleukin- (IL-) 6 and IL-12 in HFD group.
Feeding rats HFD for 6 weeks also decreased level of interferon gamma (IFN-γ).
The decreased level of IFN-γ has been shown to predict infection with infectious diseases especially viral infection.
Treatment and protection with berberine 50 mg/kg/day for 2 weeks were found to be effective against the features of insulin resistance syndrome, improved levels of insulin resistance parameters, lipid profile, antioxidant enzymes, proinflammatory cytokines, and IFN-γ.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmoud, Mohammad Ahmad& Ghareeb, Doaa A.& Sahyoun, Heba Abdelghany& Elshehawy, Ashraf Abdelhamed& Elsayed, Mohammad Mohammad. 2016. In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103954
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmoud, Mohammad Ahmad…[et al.]. In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1103954
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmoud, Mohammad Ahmad& Ghareeb, Doaa A.& Sahyoun, Heba Abdelghany& Elshehawy, Ashraf Abdelhamed& Elsayed, Mohammad Mohammad. In Vivo Interrelationship between Insulin Resistance and Interferon Gamma Production: Protective and Therapeutic Effect of Berberine. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1103954
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103954
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر