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Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats
المؤلفون المشاركون
Min, Byung Sun
Lee, Joo Young
Shin, Yu Ock
Kim, Gyo-Nam
Shin, Sung Ho
Lee, Ah Reum
Seo, Bu-Il
Kim, Min Yeong
Noh, Jeong Sook
Kwon, O Jun
Choi, Hyun Gyu
Kim, Jeong Ah
Rhee, Man Hee
Roh, Seong-Soo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The purpose of this study was to investigate the antioxidant and anti-inflammatory effects of the combined extract of Rhei rhizoma and Coptidis rhizoma (RC-mix) in experimental model of acute reflux esophagitis.
The antioxidant activity was assessed by in vitro 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays.
RC-mix was given at 100, 200, and 400 mg/kg body weight 2 h prior to induction of reflux esophagitis (RE).
After 5 h, the effects of RC-mix treated rats were compared with those of normal and control rats.
The representative flavonoid contents of RC-mix, such as sennoside A, epiberberine, coptisine, palmatine, and berberine, were detected using HPLC.
The elevated esophageal mucosa damage was markedly ameliorated by RC-mix treatment in a dose-dependent manner.
Furthermore, the administration of RC-mix reduced the increase of serum reactive oxygen species (ROS) and peroxynitrite (ONOO−).
The improvement of superoxide dismutase (SOD) and heme oxygenase-1 (HO-1) levels were marked in the group given RC-mix.
Moreover, the elevation of inflammatory mediators and cytokines by nuclear factor-kappa B (NF- κ B) activation in control rats decreased by RC-mix pretreatment.
These results indicate that RC-mix treatment reduces the pathological states of esophagitis via regulating NF- κ B mediated inflammation related to oxidative stress.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kwon, O Jun& Kim, Min Yeong& Shin, Sung Ho& Lee, Ah Reum& Lee, Joo Young& Seo, Bu-Il…[et al.]. 2016. Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1103961
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kwon, O Jun…[et al.]. Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1103961
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kwon, O Jun& Kim, Min Yeong& Shin, Sung Ho& Lee, Ah Reum& Lee, Joo Young& Seo, Bu-Il…[et al.]. Antioxidant and Anti-Inflammatory Effects of Rhei Rhizoma and Coptidis Rhizoma Mixture on Reflux Esophagitis in Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1103961
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103961
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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