Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes
المؤلفون المشاركون
Mohd Fauzi, Fazlin
Mohamad Zobir, Siti Zuraidah
Liggi, Sonia
Drakakis, Georgios
Fu, Xianjun
Bender, Andreas
Fan, Tai-Ping
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-25، 25ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-18
دولة النشر
مصر
عدد الصفحات
25
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine (TCM) still needs more scientific rationale to be proven for it to be accepted further in the West.
We are now in the position to propose computational hypotheses for the mode-of-actions (MOAs) of 45 TCM therapeutic action (sub)classes from in silico target prediction algorithms, whose target was later annotated with Kyoto Encyclopedia of Genes and Genomes pathway, and to discover the relationship between them by generating a hierarchical clustering.
The results of 10,749 TCM compounds showed 183 enriched targets and 99 enriched pathways from Estimation Score ≤ 0 and ≥ 5% of compounds/targets in a (sub)class.
The MOA of a (sub)class was established from supporting literature.
Overall, the most frequent top three enriched targets/pathways were immune-related targets such as tyrosine-protein phosphatase nonreceptor type 2 (PTPN2) and digestive system such as mineral absorption.
We found two major protein families, G-protein coupled receptor (GPCR), and protein kinase family contributed to the diversity of the bioactivity space, while digestive system was consistently annotated pathway motif, which agreed with the important treatment principle of TCM, “the foundation of acquired constitution” that includes spleen and stomach.
In short, the TCM (sub)classes, in many cases share similar targets/pathways despite having different indications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohamad Zobir, Siti Zuraidah& Mohd Fauzi, Fazlin& Liggi, Sonia& Drakakis, Georgios& Fu, Xianjun& Fan, Tai-Ping…[et al.]. 2016. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1103971
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohamad Zobir, Siti Zuraidah…[et al.]. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-25.
https://search.emarefa.net/detail/BIM-1103971
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohamad Zobir, Siti Zuraidah& Mohd Fauzi, Fazlin& Liggi, Sonia& Drakakis, Georgios& Fu, Xianjun& Fan, Tai-Ping…[et al.]. Global Mapping of Traditional Chinese Medicine into Bioactivity Space and Pathways Annotation Improves Mechanistic Understanding and Discovers Relationships between Therapeutic Action (Sub)classes. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1103971
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1103971
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر