Effect of Astragaloside IV on Neural Stem Cell Transplantation in Alzheimer’s Disease Rat Models
المؤلفون المشاركون
Haiyan, Hu
Rensong, Yang
Guoqin, Jin
Xueli, Zhang
Huaying, Xia
Yanwu, Xu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Stem cell-based therapy is a promising treatment strategy for neurodegenerative diseases such as Alzheimer’s disease (AD).
However, the mechanism underlying the maintenance of renewal and replacement capabilities of endogenous progenitor cells or engrafted stem cells in a pathological environment remains elusive.
To investigate the effect of astragaloside IV (ASI) on the proliferation and differentiation of the engrafted neural stem cells (NSCs), we cultured NSCs from the hippocampus of E14 rat embryos, treated the cells with ASI, and then transplanted the cells into the hippocampus of rat AD models.
In vitro experimentation showed that 10−5 M ASI induced NSCs to differentiate into β-tubulin III+ and GFAP+ cells.
NSCs transplantation into rat AD models resulted in improvements in learning and memory, especially in the ASI-treated groups.
ASI treatment resulted in an increase in the number of β-tubulin III+ cells in the hippocampus.
Further investigation showed that ASI inhibited PS1 expression in vitro and in vivo.
The high-dose ASI downregulated the Notch intracellular domain, whereas the low-dose ASI increased Notch-1 and NICD.
In conclusion, ASI treatment resulted in improvements in learning and memory of AD models by promoting NSC proliferation and differentiation partly through the Notch signal pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Haiyan, Hu& Rensong, Yang& Guoqin, Jin& Xueli, Zhang& Huaying, Xia& Yanwu, Xu. 2016. Effect of Astragaloside IV on Neural Stem Cell Transplantation in Alzheimer’s Disease Rat Models. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104042
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Haiyan, Hu…[et al.]. Effect of Astragaloside IV on Neural Stem Cell Transplantation in Alzheimer’s Disease Rat Models. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104042
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Haiyan, Hu& Rensong, Yang& Guoqin, Jin& Xueli, Zhang& Huaying, Xia& Yanwu, Xu. Effect of Astragaloside IV on Neural Stem Cell Transplantation in Alzheimer’s Disease Rat Models. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104042
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104042
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر