Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation
المؤلفون المشاركون
Chuang, Shuang-En
Yao, Chih-Jung
Chow, Jyh-Ming
Yang, Chia-Ming
Kuo, Hui-Ching
Chang, Chia-Lun
Lee, Hsin-Lun
Lai, I-Chun
Lai, Gi-Ming
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-20
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
The Chinese herbal mixture, Tien-Hsien Liquid (THL), has been proven to suppress the growth and invasiveness of cancer cells and is currently regarded as a complementary medicine for the treatment of cancer.
Our previous study using acute promyelocytic leukemia cells uncovered its effect on the downregulation of DNA methyltransferase 1 (DNMT1) which is often overexpressed in cancer cells resulting in the repression of tumor suppressors via hypermethylation.
Herein, we explored the effects of THL in MCF-7 breast cancer cells that also demonstrate elevated DNMT1.
The results show that THL dose-dependently downregulated DNMT1 accompanied by the induction of tumor suppressors such as p21 and p15.
THL arrested cell cycle in G2/M phase and decreased the protein levels of cyclin A, cyclin B1, phospho-pRb, and AKT.
DNMT1 inhibition was previously reported to exert a radiosensitizing effect in cancer cells through the repression of DNA repair.
We found that THL enhanced radiation-induced clonogenic cell death in MCF-7 cells and decreased the level of DNA double-strand break repair protein, Rad51.
Our observations may be the result of DNMT1 downregulation.
Due to the fact that DNMT1 inhibition is now a mainstream strategy for anticancer therapy, further clinical trials of THL to confirm its clinical efficacy are warranted.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yao, Chih-Jung& Chow, Jyh-Ming& Yang, Chia-Ming& Kuo, Hui-Ching& Chang, Chia-Lun& Lee, Hsin-Lun…[et al.]. 2016. Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104059
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yao, Chih-Jung…[et al.]. Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1104059
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yao, Chih-Jung& Chow, Jyh-Ming& Yang, Chia-Ming& Kuo, Hui-Ching& Chang, Chia-Lun& Lee, Hsin-Lun…[et al.]. Chinese Herbal Mixture, Tien-Hsien Liquid, Induces G2M Cycle Arrest and Radiosensitivity in MCF-7 Human Breast Cancer Cells through Mechanisms Involving DNMT1 and Rad51 Downregulation. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1104059
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104059
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر