Effect of Frankincense Extract on Nerve Recovery in the Rat Sciatic Nerve Damage Model
المؤلفون المشاركون
Jiang, Xiaowen
Ma, Jun
Wei, Qingwei
Feng, Xinxin
Qiao, Lu
Liu, Lin
Zhang, Binqing
Yu, Wenhui
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
This study investigated the effect of frankincense extract on peripheral nerve regeneration in a crush injury rat model.
Forty-eight Sprague-Dawley rats were randomly divided into four groups: control and frankincense extract low-, medium-, and high-dose groups.
At days 7, 14, 21, and 28 following the surgery, nerve regeneration and functional recovery were evaluated using the sciatic functional index (SFI), expression of GAP-43, and the proliferation of Schwann cells (SCs) in vivo and in vitro.
At day 7, the SFI in the frankincense extract high-dose group was significantly improved compared with the control group.
After day 14, SFI was significantly improved in the medium- and high-dose groups.
There was no significant difference in GAP-43 expression among the groups at day 7.
However, after day 14, expression of GAP-43 in the high-dose group was higher than that in the control group.
Histological evaluation showed that the injured nerve of frankincense extract high-dose group recovered better than the other groups 28 days after surgery.
Further, S100 immunohistochemical staining, MTT colorimetry, and flow cytometry assays all showed that frankincense extract could promote the proliferation of SCs.
In conclusion, frankincense extract is able to promote sciatic nerve regeneration and improve the function of a crushed sciatic nerve.
This study provides a new direction for the repair of peripheral nerve injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jiang, Xiaowen& Ma, Jun& Wei, Qingwei& Feng, Xinxin& Qiao, Lu& Liu, Lin…[et al.]. 2016. Effect of Frankincense Extract on Nerve Recovery in the Rat Sciatic Nerve Damage Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104088
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jiang, Xiaowen…[et al.]. Effect of Frankincense Extract on Nerve Recovery in the Rat Sciatic Nerve Damage Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104088
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jiang, Xiaowen& Ma, Jun& Wei, Qingwei& Feng, Xinxin& Qiao, Lu& Liu, Lin…[et al.]. Effect of Frankincense Extract on Nerve Recovery in the Rat Sciatic Nerve Damage Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104088
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104088
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر