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Wen-Luo-Tong Prevents Glial Activation and Nociceptive Sensitization in a Rat Model of Oxaliplatin-Induced Neuropathic Pain
المؤلفون المشاركون
Deng, Bo
Jia, Li-qun
Tan, Huang-ying
Pan, Lin
Song, Aiping
Wang, Yuanyuan
Xiang, Qing
Yu, Lili
Ke, Dandan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-25
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
One of the main dose-limiting complications of the chemotherapeutic agent oxaliplatin (OXL) is painful neuropathy.
Glial activation and nociceptive sensitization may be responsible for the mechanism of neuropathic pain.
The Traditional Chinese Medicine (TCM) Wen-luo-tong (WLT) has been widely used in China to treat chemotherapy induced neuropathic pain.
However, there is no study on the effects of WLT on spinal glial activation induced by OXL.
In this study, a rat model of OXL-induced chronic neuropathic pain was established and WLT was administrated.
Pain behavioral tests and morphometric examination of dorsal root ganglia (DRG) were conducted.
Glial fibrillary acidic protein (GFAP) immunostaining was performed, glial activation was evaluated, and the excitatory neurotransmitter substance P (SP) and glial-derived proinflammatory cytokine tumor necrosis factor-α (TNF-α) were analyzed.
WLT treatment alleviated OXL-induced mechanical allodynia and mechanical hyperalgesia.
Changes in the somatic, nuclear, and nucleolar areas of neurons in DRG were prevented.
In the spinal dorsal horn, hypertrophy and activation of GFAP-positive astrocytes were averted, and the level of GFAP mRNA decreased significantly.
Additionally, TNF-α mRNA and protein levels decreased.
Collectively, these results indicate that WLT reversed both glial activation in the spinal dorsal horn and nociceptive sensitization during OXL-induced chronic neuropathic pain in rats.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Bo& Jia, Li-qun& Pan, Lin& Song, Aiping& Wang, Yuanyuan& Tan, Huang-ying…[et al.]. 2016. Wen-Luo-Tong Prevents Glial Activation and Nociceptive Sensitization in a Rat Model of Oxaliplatin-Induced Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104089
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Bo…[et al.]. Wen-Luo-Tong Prevents Glial Activation and Nociceptive Sensitization in a Rat Model of Oxaliplatin-Induced Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104089
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Bo& Jia, Li-qun& Pan, Lin& Song, Aiping& Wang, Yuanyuan& Tan, Huang-ying…[et al.]. Wen-Luo-Tong Prevents Glial Activation and Nociceptive Sensitization in a Rat Model of Oxaliplatin-Induced Neuropathic Pain. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104089
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104089
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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