Traditional Chinese Medicine QPYF as Preventive Treatment for Clostridium difficile Associated Diarrhea in a Mouse Model
المؤلفون المشاركون
Zhang, Haojun
Li, Ping
Ya-Nan, Guo
Jun, Wang
Hong-Bing, Jia
Xin-Zhu, Liu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine QPYF has a good effect for treating antibiotic-associated diarrhea in clinical practice.
The aim of this study is to test its efficacy to prevent Clostridium difficile associated diarrhea (CDAD) in a mouse model.
C57BL/6 mice were infected with Clostridium difficile VPI 10463 after exposure to antimicrobial mixture.
QPYF was administered from 7 days prior to Clostridium difficile infection to 20 days after infection, and its effect was compared with no treatment and receiving placebo.
The mice were monitored for 20 days and the percent survival, disease activity index, weight loss, colon histopathology, and the levels of toxins in the feces were measured.
The expressions of TNF α, MCP-1, NF-κB p65, and phospho-NF-κB p65 in the colon were presented by immunohistochemistry.
The survival rate of QPYF group (93.75%) was higher than that of model control group (65%).
The mice treated with QPYF had a lower weight loss and disease activity index, compared to the mice with placebo.
A significantly lower level of histopathology scores, toxins in the feces, and TNF α, MCP-1, NF-κB p65, and phospho-NF-κB p65 were detected for QPYF-treated mice.
Traditional Chinese medicine QPYF showed a good preventive effect for CDAD in a mouse model.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ya-Nan, Guo& Jun, Wang& Zhang, Haojun& Hong-Bing, Jia& Li, Ping& Xin-Zhu, Liu. 2016. Traditional Chinese Medicine QPYF as Preventive Treatment for Clostridium difficile Associated Diarrhea in a Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104100
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ya-Nan, Guo…[et al.]. Traditional Chinese Medicine QPYF as Preventive Treatment for Clostridium difficile Associated Diarrhea in a Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104100
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ya-Nan, Guo& Jun, Wang& Zhang, Haojun& Hong-Bing, Jia& Li, Ping& Xin-Zhu, Liu. Traditional Chinese Medicine QPYF as Preventive Treatment for Clostridium difficile Associated Diarrhea in a Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104100
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104100
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر