The Extract of Chrysanthemum zawadskii var. latilobum Ameliorates Collagen-Induced Arthritis in Mice
المؤلفون المشاركون
Choi, Wahn Soo
Kim, Jeom-Yong
Kim, A-Ram
Kim, Hyuk Soon
Kim, Do Kyun
Lee, Jun Ho
Yoo, Young Hyo
Park, Sun Kyu
Nam, Seung Taek
Kim, Hyun Woo
Park, Young Hwan
Lee, Dajeong
Lee, Min Beom
Kim, Young Mi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Chrysanthemum zawadskii var.
latilobum (CZ) has been used for beverage or tea and also as folk medicine for the remedy of diverse inflammatory diseases.
Nevertheless, the therapeutic effect of CZ on arthritis remains to be unknown.
In this paper we aim to investigate the CZ’s antiarthritic effect and mechanism of action both in vitro and in vivo.
To assess CZ’s antiarthritic effect, mouse models of type II collagen-induced arthritis (CIA) were used.
Mice were used to gauge clinical arthritis index and histopathological changes.
Reverse transcriptase-polymerase chain reaction (RT-PCR), western blotting, electrophoretic mobility shift assay (EMSA), and other biological methods were adopted to measure CZ’s effect on arthritis and to understand the veiled mechanism of action.
CZ greatly suppressed CIA, histopathological score, bone erosion, and osteoclast differentiation.
Mechanistically, CZ inhibited the production of various inflammatory and arthritic mediators like inflammatory cytokines, matrix metalloproteinases (MMPs), and chemokines.
Of note, CZ significantly suppressed the activation of the NF-κB pathway in vivo.
CZ exerted an antiarthritic effect in CIA mice by curbing the production of crucial inflammatory and arthritis mediators.
This study warrants further investigation of CZ for the use in human rheumatoid arthritis (RA).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kim, A-Ram& Kim, Hyuk Soon& Kim, Do Kyun& Lee, Jun Ho& Yoo, Young Hyo& Kim, Jeom-Yong…[et al.]. 2016. The Extract of Chrysanthemum zawadskii var. latilobum Ameliorates Collagen-Induced Arthritis in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104116
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kim, A-Ram…[et al.]. The Extract of Chrysanthemum zawadskii var. latilobum Ameliorates Collagen-Induced Arthritis in Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1104116
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kim, A-Ram& Kim, Hyuk Soon& Kim, Do Kyun& Lee, Jun Ho& Yoo, Young Hyo& Kim, Jeom-Yong…[et al.]. The Extract of Chrysanthemum zawadskii var. latilobum Ameliorates Collagen-Induced Arthritis in Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104116
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104116
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر