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Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism
المؤلفون المشاركون
Jung, Myung-A
Oh, Dool-Ri
Kim, Youg Ran
Kim, Yujin
Choi, Eun-jin
Hunmi-Lee, Eun-jin
Bae, Donghyuck
Jo, Ara
Kim, Sunoh
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-19
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Background.
The objective of the present study was to perform a bioguided fractionation of unripe Rubus coreanus Miquel (uRC) and evaluate the lipid accumulation system involvement in its antiobesity activity as well as study the uRC mechanism of action.
Results.
After the fractionation, the BuOH fraction of uRC (uRCB) was the most active fraction, suppressing the differentiation of 3T3-L1 adipocytes in a dose-dependent manner.
Moreover, after an oral administration for 8 weeks in HFD-induced obese mice, uRCB (10 and 50 mg/kg/day) produced a significant decrease in body weight, food efficiency ratio, adipose tissue weight and LDL-cholesterol, serum glucose, TC, and TG levels.
Similarly, uRCB significantly suppressed the elevated mRNA levels of PPARγ in the adipose tissue in vivo.
Next, we investigated the antiobesity effects of ellagic acid, erycibelline, 5-hydroxy-2-pyridinemethanol, m-hydroxyphenylglycine, and 4-hydroxycoumarin isolated from uRCB.
Without affecting cell viability, five bioactive compounds decreased the lipid accumulation in the 3T3-L1 cells and the mRNA expression levels of key adipogenic genes such as PPARγ, C/EBPα, SREBP-1c, ACC, and FAS.
Conclusion.
These results suggest that uRC and its five bioactive compounds may be a useful therapeutic agent for body weight control by downregulating adipogenesis and lipogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oh, Dool-Ri& Kim, Yujin& Choi, Eun-jin& Hunmi-Lee, Eun-jin& Jung, Myung-A& Bae, Donghyuck…[et al.]. 2016. Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104144
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oh, Dool-Ri…[et al.]. Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1104144
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oh, Dool-Ri& Kim, Yujin& Choi, Eun-jin& Hunmi-Lee, Eun-jin& Jung, Myung-A& Bae, Donghyuck…[et al.]. Antiobesity Effects of Unripe Rubus coreanus Miquel and Its Constituents: An In Vitro and In Vivo Characterization of the Underlying Mechanism. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1104144
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104144
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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