Cardioprotective Effect of Electroacupuncture Pretreatment on Myocardial IschemiaReperfusion Injury via Antiapoptotic Signaling
المؤلفون المشاركون
Zhu, Bing-Mei
Shen, Weixing
Lu, Sheng-feng
Huang, Yan
Wang, Ning
Fu, Shu-ping
Li, Qian
Yu, Mei-ling
Liu, Wan-xin
Chen, Xia
Jing, Xin-yue
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
Our previous study has used RNA-seq technology to show that apoptotic molecules were involved in the myocardial protection of electroacupuncture pretreatment (EAP) on the ischemia/reperfusion (I/R) animal model.
Therefore, this study was designed to investigate how EAP protects myocardium against myocardial I/R injury through antiapoptotic mechanism.
Methods.
By using rats with myocardial I/R, we ligated the left anterior descending artery (LAD) for 30 minutes followed by 4 hr of reperfusion after EAP at the Neiguan (PC6) acupoint for 12 days; we employed arrhythmia scores, serum myocardial enzymes, and cardiac troponin T (cTnT) to evaluate the cardioprotective effect.
Heart tissues were harvested for western blot analyses for the expressions of pro- and antiapoptotic signaling molecules.
Results.
Our preliminary findings showed that EAP increased the survival of the animals along with declined arrhythmia scores and decreased CK, LDH, CK-Mb, and cTnT levels.
Further analyses with the heart tissues detected reduced myocardial fiber damage, decreased number of apoptotic cells and the protein expressions of Cyt c and cleaved caspase 3, and the elevated level of Endo G and AIF after EAP intervention.
At the same time, the protein expressions of antiapoptotic molecules, including Xiap, BclxL, and Bcl2, were obviously increased.
Conclusions.
The present study suggested that EAP protected the myocardium from I/R injury at least partially through the activation of endogenous antiapoptotic signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Sheng-feng& Huang, Yan& Wang, Ning& Shen, Weixing& Fu, Shu-ping& Li, Qian…[et al.]. 2016. Cardioprotective Effect of Electroacupuncture Pretreatment on Myocardial IschemiaReperfusion Injury via Antiapoptotic Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Sheng-feng…[et al.]. Cardioprotective Effect of Electroacupuncture Pretreatment on Myocardial IschemiaReperfusion Injury via Antiapoptotic Signaling. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Sheng-feng& Huang, Yan& Wang, Ning& Shen, Weixing& Fu, Shu-ping& Li, Qian…[et al.]. Cardioprotective Effect of Electroacupuncture Pretreatment on Myocardial IschemiaReperfusion Injury via Antiapoptotic Signaling. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر