Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic dbdb Mice
المؤلفون المشاركون
Zhao, Juan
Cao, Tong-Tong
Tian, Jing
Chen, Hui-hua
Zhang, Chen
Wei, Hong-Chang
Guo, Wei
Lu, Rong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-21
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In this study, we mainly investigated the effects of Shengmai San (SMS) on diabetic cardiomyopathy (DCM) in db/db mice.
The db/db mice were randomly divided into model group and SMS group, while C57BLKS/J inbred mice were used as controls.
After 24-week treatment, blood glucose, body weight, and heart weight were determined.
Hemodynamic changes in the left ventricle were measured using catheterization.
The myocardial structure and subcellular structural changes were observed by HE staining and electron microscopy; the myocardium collagen content was quantified by Masson staining.
To further explore the protective mechanism of SMS, we analyzed the expression profiles of fibrotic related proteins.
Compared to nondiabetic mice, db/db mice exhibited enhanced diastolic myocardial dysfunction and adverse structural remodeling.
Higher expression of profibrotic proteins and lower levels of extracellular matrix degradation were also observed.
After SMS oral administration for 24 weeks, cardiac dysfunction, hypertrophy, and fibrosis in diabetic mice were greatly improved.
Moreover, increased profibrotic protein expression was strongly reversed by SMS treatment in db/db mice.
The results demonstrate that SMS exerts a cardioprotective effect against DCM by attenuating myocardial hypertrophy and fibrosis via a TGF-β dependent pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Juan& Cao, Tong-Tong& Tian, Jing& Chen, Hui-hua& Zhang, Chen& Wei, Hong-Chang…[et al.]. 2016. Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Juan…[et al.]. Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Juan& Cao, Tong-Tong& Tian, Jing& Chen, Hui-hua& Zhang, Chen& Wei, Hong-Chang…[et al.]. Shengmai San Ameliorates Myocardial Dysfunction and Fibrosis in Diabetic dbdb Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر