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Components and Anti-HepG2 Activity Comparison of Lycopodium Alkaloids from Four Geographic Origins
المؤلفون المشاركون
Tian, Yong-Qiang
Hu, Guang-Wan
Guo, Ming-Quan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-28
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Lycopodium japonicum Thunb.
has attracted great interests due to its rich alkaloids with significant anticancer activity.
However, significant chemical differences often exist in a plant species from different geographic origins and affect its quality and bioactivities.
Thus, it is urgent to reveal their chemical and biological distinctions at the molecular level.
In this context, a comparative chemical analysis of LAs using HPLC-UV-ESI-MS/MS was firstly conducted and resulted in the detection of 46 LAs, 28 of which were identified, and a series of unique LAs markers, such as peaks 2, 9, 10, and 11, were further found to be characteristic LAs and selected as markers from four different origins for their quality control.
In parallel, the comparative bioactivity assay revealed that the total LAs from Hubei province exhibited much higher inhibitory rate at 65.95% against HepG2 cells than those at 26.72%, 20.26%, and 33.62% for Kenya, Guangxi province, and Zhejiang province in China, respectively.
To this end, significant chemical fingerprinting differences and discrepancies in bioactivity of LAs were explored firstly, which could provide valuable information for quality control and further activity studies on LAs from different sources and promote their better pharmaceutical applications in the future as well.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tian, Yong-Qiang& Hu, Guang-Wan& Guo, Ming-Quan. 2016. Components and Anti-HepG2 Activity Comparison of Lycopodium Alkaloids from Four Geographic Origins. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104159
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tian, Yong-Qiang…[et al.]. Components and Anti-HepG2 Activity Comparison of Lycopodium Alkaloids from Four Geographic Origins. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1104159
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tian, Yong-Qiang& Hu, Guang-Wan& Guo, Ming-Quan. Components and Anti-HepG2 Activity Comparison of Lycopodium Alkaloids from Four Geographic Origins. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1104159
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104159
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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