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The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method
المؤلفون المشاركون
Kong, Lingti
Song, Chunli
Ye, Linhu
Guo, Daohua
Yu, Meiling
Xing, Rong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Vinpocetine is a derivative of the alkaloid vincamine, which had been prescribed for chronic cerebral vascular ischemia and acute ischemic stroke or used as a dietary supplement for its several different mechanisms of biological activities.
However, information on the cytochrome P450 (CYP) enzyme-mediated drug metabolism has not been previously studied.
The present study was performed to investigate the effects of vinpocetine on CYPs activity, and cocktail method was used, respectively.
To evaluate the effects of vinpocetine on the activity of human CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP2E1, human liver microsomes were utilized to incubate with the mixed CYPs probe substrates and the target components.
The results indicate that vinpocetine exhibited weak inhibitory effect on the CYP2C9, where the IC50 value is 68.96 μM, whereas the IC50 values for CYP3A4, CYP2C19, CYP2D6, and CYP2E1 were all over range of 100 μM, which showed that vinpocetine had no apparent inhibitory effects on these CYPs.
In conclusion, the results indicated that drugs metabolized by CYP2C9 coadministrated with vinpocetine may require attention or dose adjustment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kong, Lingti& Song, Chunli& Ye, Linhu& Guo, Daohua& Yu, Meiling& Xing, Rong. 2016. The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104182
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kong, Lingti…[et al.]. The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1104182
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kong, Lingti& Song, Chunli& Ye, Linhu& Guo, Daohua& Yu, Meiling& Xing, Rong. The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104182
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104182
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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