JiaWeiDangGui Decoction Ameliorates Proteinuria and Kidney Injury in Adriamycin-Induced Rat by Blockade of TGF-βSmad Signaling
المؤلفون المشاركون
Wei, Ming-Gang
Sun, Wei
He, Wei-ming
Ni, Li
Yang, Yan-yu
Lu, Xun
Chen, Lin
Xiong, Pei-hua
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
JiaWeiDangGui (JWDG) decoction has anti-inflammatory and antifibrotic effects, which is used widely for the treatment of various kidney diseases.
In previous studies, we have found that JWDG decoction can reduce the quantity of proteinuria, but the mechanism was unknown.
Here, we studied the protective effect of JWDG decoction in adriamycin-induced nephropathy on rat.
JWDG decoction, at 10 mL/kg/d, 20 mL/kg/d, and 40 mL/kg/d, was orally administered daily for 12 weeks.
Therapeutic effects and mechanisms were further examined.
The kidney function related biochemical indexes were measured by automatic biochemistry analyzer.
The pathomorphological changes were observed using light and transmission electron microcopies.
The proteins expressions of podocin, nephrin, collagen IV, and fibronectin (FN) were examined by immunohistochemical staining, and key proteins involved in TGF-β/Smad signaling were evaluated by RT-PCR and western blotting.
Compared with vehicle-treated controls, JWDG decoction decreased the quantity of proteinuria; reduced glomerulosclerotic lesions induced by ADR; and preserved the expression of podocin and nephrin.
JWDG decoction also inhibited the expression of the collagen IV, FN, and fibrogenic TGF-β.
Further studies revealed that inhibition of renal fibrosis was associated with the blockade of TGF-β/Smad signaling and downregulation of snail expression dose dependently.
JWDG decoction prevents proteinuria production, podocyte dysfunction, and kidney injury in adriamycin nephropathy by inhibiting TGF-β/Smad signaling.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wei, Ming-Gang& He, Wei-ming& Lu, Xun& Ni, Li& Yang, Yan-yu& Chen, Lin…[et al.]. 2016. JiaWeiDangGui Decoction Ameliorates Proteinuria and Kidney Injury in Adriamycin-Induced Rat by Blockade of TGF-βSmad Signaling. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104183
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wei, Ming-Gang…[et al.]. JiaWeiDangGui Decoction Ameliorates Proteinuria and Kidney Injury in Adriamycin-Induced Rat by Blockade of TGF-βSmad Signaling. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104183
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wei, Ming-Gang& He, Wei-ming& Lu, Xun& Ni, Li& Yang, Yan-yu& Chen, Lin…[et al.]. JiaWeiDangGui Decoction Ameliorates Proteinuria and Kidney Injury in Adriamycin-Induced Rat by Blockade of TGF-βSmad Signaling. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104183
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104183
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر