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Miconia sp. Increases mRNA Levels of PPAR Gamma and Inhibits Alpha Amylase and Alpha Glucosidase
المؤلفون المشاركون
Rivas Morales, Catalina
Leos-Rivas, Catalina
Ortiz Martínez, David Mizael
de la Garza-Ramos, Myriam Angelica
Verde-Star, Maria Julia
Nuñez-Gonzalez, Maria Adriana
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-13
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Diabetes mellitus is a public health problem worldwide.
For this reason, ethanolic extract of Miconia sp.
from Oaxaca, Mexico, was selected in search of an alternative against this disease.
The effect of Miconia sp.
on mRNA expression of PPARγ on cell line 3T3-L1, its effect on alpha amylase and alpha glucosidase, lipid accumulation during adipogenesis, and cell viability on VERO cells were evaluated.
The mRNA levels of PPARγ increased on 1.393 ± 0.008 folds, lipid accumulation was increased by 29.55% with Miconia sp.
extract and 34.57% with rosiglitazone, and α-amylase and α-glycosidase were inhibited with IC50 values from 28.23 ± 2.15 μg/mL and 1.95 ± 0.15 μg/mL, respectively; the IC50 on antiproliferative activity on VERO cells was 314.54 ± 45.40 μg/mL.
In case of α-amylase and α-glycosidase assays, IC50 (inhibitory concentration 50) refers to necessary extract amounts to inhibit 50% of enzymatic activity.
On the other hand, on antiproliferative activity, IC50 (inhibitory concentration 50) refers to necessary extract amounts to inhibit 50% of cell proliferation.
It was concluded that the compounds present in Miconia sp.
ethanolic extract increase mRNA expression of PPARγ, inhibit α-amylase and α-glucosidase, and increase lipid accumulation.
It constitutes an alternative as adjuvant in diabetes mellitus treatment; therefore, we recommend continuing identifying the compounds responsible for its promising in vivo antidiabetic activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ortiz Martínez, David Mizael& Rivas Morales, Catalina& de la Garza-Ramos, Myriam Angelica& Verde-Star, Maria Julia& Nuñez-Gonzalez, Maria Adriana& Leos-Rivas, Catalina. 2016. Miconia sp. Increases mRNA Levels of PPAR Gamma and Inhibits Alpha Amylase and Alpha Glucosidase. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104192
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ortiz Martínez, David Mizael…[et al.]. Miconia sp. Increases mRNA Levels of PPAR Gamma and Inhibits Alpha Amylase and Alpha Glucosidase. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1104192
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ortiz Martínez, David Mizael& Rivas Morales, Catalina& de la Garza-Ramos, Myriam Angelica& Verde-Star, Maria Julia& Nuñez-Gonzalez, Maria Adriana& Leos-Rivas, Catalina. Miconia sp. Increases mRNA Levels of PPAR Gamma and Inhibits Alpha Amylase and Alpha Glucosidase. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104192
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104192
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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