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Personalized Kampo Medicine Facilitated Both Cytotoxic T Lymphocyte Response and Clinical Benefits Induced by Personalized Peptide Vaccination for Advanced Esophageal Cancer
المؤلفون المشاركون
Okuda, K.
Yamada, Akira
Shichijo, Shigeki
Muroya, Daisuke
Sakamoto, Shinjiro
Naito, Masayasu
Morita, Michi
Yamaguchi, Rin
Yutani, Shigeru
Itoh, Kyogo
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We retrospectively evaluated if personalized Kampo medicine (PKM) could facilitate CTL responses and clinical benefits induced by personalized peptide vaccination (PPV), in which HLA-matched vaccines were selected and administered based on the preexisting host immunity, for advanced esophageal cancer (aEC) patients.
Among 34 aEC patients entered in the clinical study, 23 patients received PKM and PPV without ( n = 12 ) or with chemotherapy ( n = 11 ), while the remaining 11 patients did not receive PKM but received PPV without ( n = 6 ) or with chemotherapy ( n = 5 ), respectively.
Incidence of adverse events was significantly lower or higher in PKM and PPV arm ( n = 23 ) or PPV and chemotherapy arm ( n = 16 ) as compared to that of the counter arm ( n = 11 or 18), respectively.
Postvaccination PBMCs from the patients undergoing PKM and PPV showed significantly higher CTL responses as compared to the counter arm.
The median progression-free survival (PFS) or median survival time (MST) of 34 patients was 2.9 or 7.6 months, respectively.
The combination therapy in PPV and PKM arm, but not that in PPV and chemotherapy arm, significantly ( P = 0.02 ) prolonged MST.
These results could warrant a next step of prospective clinical study of PKM and PPV for aEC patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muroya, Daisuke& Yutani, Shigeru& Shichijo, Shigeki& Yamada, Akira& Sakamoto, Shinjiro& Naito, Masayasu…[et al.]. 2016. Personalized Kampo Medicine Facilitated Both Cytotoxic T Lymphocyte Response and Clinical Benefits Induced by Personalized Peptide Vaccination for Advanced Esophageal Cancer. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104243
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muroya, Daisuke…[et al.]. Personalized Kampo Medicine Facilitated Both Cytotoxic T Lymphocyte Response and Clinical Benefits Induced by Personalized Peptide Vaccination for Advanced Esophageal Cancer. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1104243
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muroya, Daisuke& Yutani, Shigeru& Shichijo, Shigeki& Yamada, Akira& Sakamoto, Shinjiro& Naito, Masayasu…[et al.]. Personalized Kampo Medicine Facilitated Both Cytotoxic T Lymphocyte Response and Clinical Benefits Induced by Personalized Peptide Vaccination for Advanced Esophageal Cancer. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1104243
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104243
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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