Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats
المؤلفون المشاركون
Cui, Fangqiang
Gao, Yanbin
Liu, Jing
Zhao, Wenjing
Zou, Dawei
Wu, Xiaoming
Tian, Nianxiu
Wang, Xiaolei
Tong, Yu
Zhu, Zhi-Yao
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-08
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diabetic nephropathy (DN) has been the leading cause of end-stage renal disease (ESRD).
Podocyte apoptosis is a main mechanism of progression of DN.
It has been demonstrated that activated P38 and caspase-3 induced by oxidative stress mainly account for increased podocyte apoptosis and proteinuria in DN.
Meanwhile, Tongxinluo (TXL) can ameliorate renal structure disruption and dysfunction in DN patients in our clinical practice.
However, the effect of TXL on podocyte apoptosis and P38 pathway remains unclear.
To explore the effect of TXL on podocyte apoptosis and its molecular mechanism in DN, our in vivo and in vitro studies were performed.
TXL attenuated oxidative stress in podocyte in DN in our in vivo and in vitro studies.
Moreover, TXL inhibited the activation of P38 and caspase-3.
Bcl-2 and Bax expression was partially restored by TXL treatment in our in vivo and in vitro studies.
More importantly, TXL decreased podocyte apoptosis in diabetic rats and high glucose cultured podocyte.
In conclusion, TXL protects podocyte from apoptosis in DN, partially through its antioxidant effect and inhibiting of the activation of P38 and caspase-3.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cui, Fangqiang& Gao, Yanbin& Zhao, Wenjing& Zou, Dawei& Zhu, Zhi-Yao& Wu, Xiaoming…[et al.]. 2016. Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104248
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cui, Fangqiang…[et al.]. Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104248
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cui, Fangqiang& Gao, Yanbin& Zhao, Wenjing& Zou, Dawei& Zhu, Zhi-Yao& Wu, Xiaoming…[et al.]. Effect of Tongxinluo on Podocyte Apoptosis via Inhibition of Oxidative Stress and P38 Pathway in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104248
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104248
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر