Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System
المؤلفون المشاركون
Shi, Jin-Li
Liu, Yong
Li, Jian
Liu, Qian-tong
Chen, Yi
Liu, Jie
Guo, Jian-You
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Quercitrin is a well-known flavonoid that is contained in Flos Albiziae, which has been used for the treatment of anxiety.
The present study investigated the anxiolytic-like effects of quercitrin in experimental models of anxiety.
Compared with the control group, repeated treatment with quercitrin (5.0 and 10.0 mg/kg/day, p.o.) for seven days significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze.
In the light/dark box test, quercitrin exerted an anxiolytic-like effect at 5 and 10 mg/kg.
In the marble-burying test, quercitrin (5.0 and 10.0 mg/kg) also exerted an anxiolytic-like effect.
Furthermore, quercitrin did not affect spontaneous locomotor activity.
The anxiolytic-like effects of quercitrin in the elevated plus maze and light/dark box test were blocked by the serotonin-1A (5-hydroxytryptamine-1A (5-H T 1A )) receptor antagonist WAY-100635 (3.0 mg/kg, i.p.) but not by the γ-aminobutyric acid-A (GAB A A ) receptor antagonist flumazenil (0.5 mg/kg, i.p.).
The levels of brain monoamines (5-HT and dopamine) and their metabolites (5-hydroxy-3-indoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid) were decreased after quercitrin treatment.
These data suggest that the anxiolytic-like effects of quercitrin might be mediated by 5-H T 1A receptors but not by benzodiazepine site of GAB A A receptors.
The results of the neurochemical studies suggest that these effects are mediated by modulation of the levels of monoamine neurotransmitters.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jian& Liu, Qian-tong& Chen, Yi& Liu, Jie& Shi, Jin-Li& Liu, Yong…[et al.]. 2016. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104292
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jian…[et al.]. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104292
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jian& Liu, Qian-tong& Chen, Yi& Liu, Jie& Shi, Jin-Li& Liu, Yong…[et al.]. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104292
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104292
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر