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Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System
المؤلفون المشاركون
Shi, Jin-Li
Liu, Yong
Li, Jian
Liu, Qian-tong
Chen, Yi
Liu, Jie
Guo, Jian-You
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Quercitrin is a well-known flavonoid that is contained in Flos Albiziae, which has been used for the treatment of anxiety.
The present study investigated the anxiolytic-like effects of quercitrin in experimental models of anxiety.
Compared with the control group, repeated treatment with quercitrin (5.0 and 10.0 mg/kg/day, p.o.) for seven days significantly increased the percentage of entries into and time spent on the open arms of the elevated plus maze.
In the light/dark box test, quercitrin exerted an anxiolytic-like effect at 5 and 10 mg/kg.
In the marble-burying test, quercitrin (5.0 and 10.0 mg/kg) also exerted an anxiolytic-like effect.
Furthermore, quercitrin did not affect spontaneous locomotor activity.
The anxiolytic-like effects of quercitrin in the elevated plus maze and light/dark box test were blocked by the serotonin-1A (5-hydroxytryptamine-1A (5-H T 1A )) receptor antagonist WAY-100635 (3.0 mg/kg, i.p.) but not by the γ-aminobutyric acid-A (GAB A A ) receptor antagonist flumazenil (0.5 mg/kg, i.p.).
The levels of brain monoamines (5-HT and dopamine) and their metabolites (5-hydroxy-3-indoleacetic acid, 3,4-dihydroxyphenylacetic acid, and homovanillic acid) were decreased after quercitrin treatment.
These data suggest that the anxiolytic-like effects of quercitrin might be mediated by 5-H T 1A receptors but not by benzodiazepine site of GAB A A receptors.
The results of the neurochemical studies suggest that these effects are mediated by modulation of the levels of monoamine neurotransmitters.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Jian& Liu, Qian-tong& Chen, Yi& Liu, Jie& Shi, Jin-Li& Liu, Yong…[et al.]. 2016. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104292
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Jian…[et al.]. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1104292
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Jian& Liu, Qian-tong& Chen, Yi& Liu, Jie& Shi, Jin-Li& Liu, Yong…[et al.]. Involvement of 5-HT1A Receptors in the Anxiolytic-Like Effects of Quercitrin and Evidence of the Involvement of the Monoaminergic System. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1104292
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104292
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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