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Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape (Vitis coignetiae) in the Rat Thoracic Aorta
المؤلفون المشاركون
Ha, Sang Keun
Park, Ho-Young
Ryu, Mee-Ra
Kim, Yoonsook
Park, Yongkon
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-20
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The vasorelaxant effects of dealcoholized wild grape (Vitis coignetiae) wine were investigated with isolated rat thoracic aorta.
In our present study, we demonstrate that wild grape wine powder (WGWP) induced relaxation of aortic rings preconstricted with norepinephrine in a dose-dependent manner (at concentrations ranging from 0.1 to 1 mg/mL).
The vasorelaxant effect of WGWP was dependent on intact endothelia, which was attenuated by incubation with inhibitors of endothelium-derived relaxing factors, such as NG-nitro-L-arginine (nitric oxide synthase inhibitor), methylene blue (guanylate cyclase inhibitor), and indomethacin (cyclooxygenase inhibitor).
Moreover, treatment with WGWP and atropine (muscarinic receptor antagonist) or diphenylhydramine (histamine receptor antagonist) significantly inhibited endothelium-dependent vasorelaxation.
Our results suggest that WGWP induces relaxation in rat aortic rings in an endothelium-dependent manner.
Results further indicate that this effect occurs via nitric oxide-cGMP pathway and prostacyclin-cAMP pathway through a muscarinic receptor and histamine receptor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ha, Sang Keun& Park, Ho-Young& Ryu, Mee-Ra& Kim, Yoonsook& Park, Yongkon. 2016. Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape (Vitis coignetiae) in the Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104303
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ha, Sang Keun…[et al.]. Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape (Vitis coignetiae) in the Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1104303
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ha, Sang Keun& Park, Ho-Young& Ryu, Mee-Ra& Kim, Yoonsook& Park, Yongkon. Endothelium-Dependent Vasorelaxant Effects of Dealcoholized Wine Powder of Wild Grape (Vitis coignetiae) in the Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1104303
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104303
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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