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Yupingfeng Pulvis Regulates the Balance of T Cell Subsets in Asthma Mice
المؤلفون المشاركون
Cai, Xueting
Wang, Zhigang
Pang, Zhonghua
Wang, Dawei
Ye, Juan
Su, Kelei
Sun, Xiaoyan
Li, Jing
Hu, Chunping
Cao, Peng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
Yupingfeng Pulvis (HFBP) had played an active role in many diseases, especially respiratory tract infections.
Exploring the possible prevention mechanism of HFBP may provide new ideas in clinical applications for this well-known herbal formula.
Purpose.
To study the possible mechanisms of therapy effect of HFBP on asthma mice via regulating the balance of Tregs and Th17 cells.
Method.
The female BALB/c mice were divided into five groups: control group, model group, prednisone (5.5 mg/kg) group, and 22 g/kg HFBP and 44 g/kg HFBP groups.
Ovalbumin was used to make the asthma model of mice; the drug was ig administered daily after atomization for consecutive 15 d.
The mice were killed after the last administration.
The paraffin-embedded tissue sections of the lungs were stained by H&E.
Tregs and Th17 cells in bronchoalveolar lavage fluid were detected by flow cytometry.
IL-4, TGF-β, and TNF-α in the serum were detected by ELISA assay.
Results.
HFBP could alleviate the inflammation in the lung tissue of mice, decrease the proportion of Th17 cells, and increase the proportion of Treg cells in bronchoalveolar lavage fluid.
HFBP could decrease IL-4 and TNF-α level and increase TGF-β level in blood.
Conclusion.
HFBP could treat the asthma through impacting the balance of Th17 cells and Treg cells as well as the levels of related inflammatory cytokines in asthma mice.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Zhigang& Cai, Xueting& Pang, Zhonghua& Wang, Dawei& Ye, Juan& Su, Kelei…[et al.]. 2016. Yupingfeng Pulvis Regulates the Balance of T Cell Subsets in Asthma Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104308
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Zhigang…[et al.]. Yupingfeng Pulvis Regulates the Balance of T Cell Subsets in Asthma Mice. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1104308
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Zhigang& Cai, Xueting& Pang, Zhonghua& Wang, Dawei& Ye, Juan& Su, Kelei…[et al.]. Yupingfeng Pulvis Regulates the Balance of T Cell Subsets in Asthma Mice. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1104308
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104308
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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