Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs
المؤلفون المشاركون
Asiedu-Gyekye, I. J.
Kukuia, Kennedy Kwami Edem
Nyarko, Alexander Kwadwo
Adjei, Samuel
Frimpong-Manso, S.
Seidu, Abdulai Mahmood
Antwi-Boasiako, Charles
N’guessan, Benoit Banga
Zobi, Jonathan
Tettey, Abraham Terkpertey
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-14
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
This study investigated the elemental composition of unsweetened natural cocoa powder (UNCP), its effect on nitric oxide, and its hepatoprotective potential during simultaneous administration with high-dose artemether/lumefantrine (A/L).
Method.
Macro- and microelements in UNCP were analyzed with EDXRF spectroscopy.
Thirty (30) male guinea-pigs were then divided into five groups.
For groups 3 (low-dose), 4 (medium-dose), and 5 (high-dose), the animals received oral UNCP prophylactically for 14 days.
Group 1 received distilled water (14 days) and group 2 A/L for the last 3 days (days 12 to 14).
After euthanisation, biochemical and histopathological examinations were carried out in all groups.
Results.
Phytochemical analysis of UNCP showed the presence of saponins, flavonoids, tannins, and cardiac glycosides.
Thirty-eight (38) macro- and microelements were found.
UNCP produced significant decreases in ALT, ALP, GGT, and AST levels.
A significant increase in total protein levels was observed during A/L+UNCP administration in comparison to 75 mg/kg A/L group.
Histopathological examinations buttressed the protective effects of cocoa administration.
UNCP administration increased nitric oxide levels 149.71% ( P < 0.05 ) compared to controls.
Conclusion.
UNCP increases nitric oxide levels and has hepatoprotective potential during A/L administration.
A high level of copper was observed which may be detrimental during high daily consumptions of UNCP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Asiedu-Gyekye, I. J.& Kukuia, Kennedy Kwami Edem& Seidu, Abdulai Mahmood& Antwi-Boasiako, Charles& N’guessan, Benoit Banga& Frimpong-Manso, S.…[et al.]. 2016. Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104348
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Asiedu-Gyekye, I. J.…[et al.]. Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1104348
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Asiedu-Gyekye, I. J.& Kukuia, Kennedy Kwami Edem& Seidu, Abdulai Mahmood& Antwi-Boasiako, Charles& N’guessan, Benoit Banga& Frimpong-Manso, S.…[et al.]. Unsweetened Natural Cocoa Powder Has the Potential to Attenuate High Dose Artemether-Lumefantrine-Induced Hepatotoxicity in Non-Malarious Guinea Pigs. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1104348
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104348
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر