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Radix Astragali Stimulates p38 MARK Phosphorylation in Pediatric Patients with β-Thalassemia
المؤلفون المشاركون
Lu, Zhuoming
Qian, Xinhua
Zhang, Chunhong
Chen, Zhiwen
Du, Guangliang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A previous study conducted by our group demonstrated that Radix Astragali compounded with Codonopsis pilosula and Plastrum testudinis was effective in treating pediatric β-thalassemia in a randomized, controlled clinical trial.
However, the mechanism of action that underpins this treatment remains to be elucidated.
Blood was collected from patients participating in this clinical trial and nucleated red blood cell-enriched mononuclear cells were isolated to facilitate the extraction of RNA and protein.
RT-PCR was used to monitor the expression of globin genes and p38 MAPK, and total and phosphorylated p38 MAPK expression was assessed using Western blot analysis.
Expression of α-, β-, and Aγ-globin mRNAs was not significantly affected following treatment with R.
Astragali or the compounded formulation.
However, Gγ-globin mRNA levels increased significantly in both treatment groups (when compared with pretreatment levels) following 12 weeks of treatment.
Moreover, posttreatment Gγ-globin expression was significantly higher in both treatment groups compared with the control group.
Although neither p38 MAPK mRNA nor protein levels were affected by the treatments, posttreatment phosphorylation of p38 MAPK was significantly increased in the R.
Astragali and compounded formulation groups compared with the control group.
These data suggest that the molecular mechanisms that underpin the efficacious use of R.
Astragali (and its compounded formulation) in pediatric β-thalassemia treatment facilitate the induction of Gγ-globin expression following activation of p38 MAPK.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lu, Zhuoming& Qian, Xinhua& Zhang, Chunhong& Chen, Zhiwen& Du, Guangliang. 2016. Radix Astragali Stimulates p38 MARK Phosphorylation in Pediatric Patients with β-Thalassemia. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104352
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lu, Zhuoming…[et al.]. Radix Astragali Stimulates p38 MARK Phosphorylation in Pediatric Patients with β-Thalassemia. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1104352
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lu, Zhuoming& Qian, Xinhua& Zhang, Chunhong& Chen, Zhiwen& Du, Guangliang. Radix Astragali Stimulates p38 MARK Phosphorylation in Pediatric Patients with β-Thalassemia. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1104352
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104352
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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