Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats
المؤلف
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-09
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Postprandial hyperglycemia is a predisposing factor for vascular dysfunction and organ damage.
α-glucosidase is a hydrolytic enzyme that increases the glucose absorption rate and subsequently elevates blood glucose levels.
Garlic (Allium sativum L.) is a rich source of several phytonutrients, including thiosulfinate (THIO).
The aim of this study was to evaluate the ability of THIO, a potent inhibitor of intestinal α-glucosidase, to reduce postprandial blood glucose.
Male albino rats were randomly assigned to five different groups ( n = 10 /group).
Group 1 served as the control group.
Groups 2–5 were injected intraperitoneally with a single dose of streptozotocin (STZ) to induce diabetes.
Group 2 comprised untreated diabetic rats.
Groups 3 and 4 contained diabetic rats that were given THIO orally (20 mg/kg body weight/day and 40 mg/kg body weight/day, resp.).
Group 5 was the positive control having diabetic rats treated orally with acarbose (10 mg/kg body weight/day; positive control).
Diabetic rats treated with THIO displayed a significant blood glucose reduction ( p < 0.001 and < 0.01 by analysis of variance, resp.) and a significant elevation in insulin compared with that of untreated rats.
THIO is an effective noncompetitive intestinal α-glucosidase inhibitor that promotes hypoglycemic action ( p < 0.001 ) in STZ-injected rats.
THIO is a promising agent for the management of postprandial hyperglycemia.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Malki, Abdulrahman L.. 2016. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Malki, Abdulrahman L.. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Malki, Abdulrahman L.. Inhibition of α-Glucosidase by Thiosulfinate as a Target for Glucose Modulation in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1104371
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1104371
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر